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Registration Dossier
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EC number: 201-132-3 | CAS number: 78-67-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Title:
- No information
- Author:
- Rusin, V.Y.: Gig. Truda Profzabol. (1958), 247-251|(published 1959);|cited in: TSCATS: OTS 0000937, Doc. ID. FYI-OTS-0794-0937,|Haskell Laboratory for E.I. Dupont de Nemours & Co., 1-30-84
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- EC Number:
- 201-132-3
- EC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Cas Number:
- 78-67-1
- Molecular formula:
- C8H12N4
- IUPAC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Details on test material:
- 2,2'-azobisisobutyronitrile; no data on purity of the compound
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- 2 h/d
Doses / concentrations
- Remarks:
- no data
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Post-exposure period: none
Results and discussion
Results of examinations
- Description (incidence):
- one rat died
- Description (incidence and severity):
- Morphological changes similar to those observed after intoxication with nitriles and cyanides were found.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Five rats were exposed to vapours produced by heating of the test
substance to 70-80 degrees Centigrade. According to
the authors, HCN concentration did not exceed 1.4-1.6 mg/m3
(1.4-1.6x10E-3 mg/l). One rat died. Morphological changes similar to
those observed after intoxication with nitriles and cyanides were found.
Only secondary literature; no
further data.
Applicant's summary and conclusion
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