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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Title:
No information
Author:
Rusin, V.Y.: Gig. Truda Profzabol. (1958), 247-251|(published 1959);|cited in: TSCATS: OTS 0000937, Doc. ID. FYI-OTS-0794-0937,|Haskell Laboratory for E.I. Dupont de Nemours & Co., 1-30-84

Materials and methods

GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
2,2'-azobisisobutyronitrile; no data on purity of the compound

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Duration of treatment / exposure:
10 days
Frequency of treatment:
2 h/d
Doses / concentrations
Remarks:
no data
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Post-exposure period: none

Results and discussion

Results of examinations

Description (incidence):
one rat died
Description (incidence and severity):
Morphological changes similar to those observed after intoxication with nitriles and cyanides were found.

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Five rats were exposed to vapours produced by heating of the test substance to 70-80 degrees Centigrade. According to
the authors, HCN concentration did not exceed 1.4-1.6 mg/m3 (1.4-1.6x10E-3 mg/l). One rat died. Morphological changes similar to those observed after intoxication with nitriles and cyanides were found. Only secondary literature; no
further data.

Applicant's summary and conclusion