Registration Dossier

Administrative data

Description of key information

LD50 oral (rat), p-Cresol = 207 mg/kg bw

LD50 oral (rat), m-Cresol = 242 mg/kg bw

LD50 dermal (rat), p-Cresol = 750 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
not specified
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from Supplier's Safety Data Sheet
Species:
rat
Route of administration:
oral: unspecified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
242 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 3 based on GHS criteria
Endpoint:
acute toxicity: oral
Type of information:
not specified
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from Supplier's Safety Data Sheet
Species:
rat
Route of administration:
oral: unspecified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
207 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 3 based on GHS criteria
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
207 mg/kg bw
Quality of whole database:
Reliability 4 (Data from supplier's Safety Data Sheet)

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
not specified
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from Supplier's Safety Data Sheet
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
130 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 2 based on GHS criteria
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
750 mg/kg bw
Quality of whole database:
Reliability 4 (Data from supplier's Safety Data Sheet)

Additional information

Justification for classification or non-classification

Based on the available data reported in the supplier's Safety Data Sheet and the harmonized classification, the registered substance is classified Acute Tox cat. 3, H301 and Acute Tox cat. 3, H311 according to the classification criteria of GHS regulation.