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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6 March - 28 June 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
27 July 1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
flask method
Specific details on test material used for the study:
Name:
CAS No.: Oleyl Lactate (Dermol OL)
42175-36-0 (formally known as)
EC NO:
Chemical Name

Physical state: 946-088-2 (assigned since pre-registration)
Reaction Products of (Z)-octadec-9-enol and lactic acid
Clear yellow liquid
Sponsor lot number: P7610
Purity: 100%
Molecular weight: 340.5405 g/mol
Arrival date: 7 February 2018
Re-test date: 31 January 2020
Storage conditions: Room temperature (15 to 30°C)

Water solubility:
ca. 0.013 µg/L
Conc. based on:
test mat.
Incubation duration:
ca. 7 d
Temp.:
20 °C
pH:
6.69

Water Solubility Results

 

Sample Ref

Sampling Time

Elapsed Hours

Vessel 1 Conc. (µg/mL)

Vessel 1 Mean Conc. (µg/mL)

Vessel 2 Conc. (µg/mL)

Vessel 2 Mean Conc. (µg/mL)

1a*

17 May 2018 09:15

23.67

0.02655

0.02191

0.34023

0.36160

1b*

0.01727

0.38296

2a*

18 May 2018 07:55

46.33

0.00807

0.00887

0.04769

0.04709

2b*

0.00966

0.04649

3a*

18 May 2018 09:15

51.67

0.00930

0.00933

0.04686

0.05021

3b*

0.00936

0.05355

4a

21 May 2018 07:55

118.33

0.01124

0.01173

0.01486

0.01453

4b

0.01222

0.01419

5a

21 May 2018 13:15

123.67

0.01263

0.01160

0.01369

0.01368

5b

0.01056

0.01366

6a

22 May 2018 08:00

142.42

0.01180

0.01312

0.01443

0.01388

6b

0.01444

0.01332

7a

22 May 2018 13:10

147.58

0.01092

0.01073

0.01459

0.01344

7b

0.01053

0.01228

8a

23 May 2018 07:55

166.33

0.01478

0.01382

0.01175

0.01278

8b

0.01286

0.01380

9a

23 May 2018 13:30

171.92

0.01141

0.01275

0.01280

0.01290

9b

0.01408

0.01299

10a

24 May 2018 07:45

190.17

0.01333

0.01313

0.01291

0.01188

10b

0.01293

0.01085

 

 

 

Mean

0.01241

l Mean:

0.01329

 

 

 

SD:

0.001

SD:

0.001

 

 

 

% RSD:

11.36

% RSD:

8.51

 

 

 

 

 

Overall Mean:

0.01285

 

 

 

 

 

SD:

0.001

 

 

 

 

 

%RSD:

10.37

*Samples not used for mean calculations

Conclusions:
The water solubility of the test substance was found to be 0.013 µg/mL at 20 °C, under the conditions of the test.
Executive summary:

In this guideline (OECD 105) study, [conducted with GLP certification], the water solubility of the test substance was found to be 0.013 µg/ml at 20°C.

Description of key information

Study conducted to recognised testing guidelines [with GLP certification].

Key value for chemical safety assessment

Water solubility:
0.013 µg/L
at the temperature of:
20 °C

Additional information

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