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EC number: 446-240-3 | CAS number: -
Table 1. Individual skin reactions
S = dryness of the skin
Mean scores per organism at 24, 48 and 72h:
1: total = 6; mean score = 2.0
2: total = 4; mean score = 1.3
3: total = 6; mean score = 2.0
1: total = 0; mean score = 0.0
2. total = 0; mean score = 0.0
3. total = 0; mean score = 0.0
The study was performed to OECD TG 404 and EU Method B.4 in accordance with GLP to assess the primary skin irritancy potential of the test item in New Zealand White rabbits. Following single 4-Hour, semi-occluded applications to the intact rabbit skin. 0.5 ml of the test material was introduced under a gauze patch and placed in position on the clipped skin via semi-occlusive dressing to assess the irritancy potential of the test item. The patch was secured in position with a strip of surgical bandage. After 4 hours of exposure to the test item, the patches were removed, and individual dose sites were scored at approximately 1, 24, 48, and 72 hours. Daily observations were made up to day 15 as applicable. A single 4-Hour, semi occluded application of the test item to the intact skin of three rabbits produced very slight or well-defined erythema (score = 1 or 2) at all treated skin sites at 24 to 72 hours after patch removal and up to day 7 or 8 in two sites. Mean scores for following grading at 24, 48 and 72h were 2.0, 1.3 and 2.00 in erythema and eschar and 0.0 in all sites for the edema scoring criteria. Under the conditions of the study, the test item is not considered to be a skin irritant.
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