Polyethylene polyamine, pentaethylenehexamine fraction

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1963

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Undiluted application of test substance into the eye of rabbits.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Polyethylene polyamine, pentaethylenehexamine fraction

EC Number:

701-266-7

Molecular formula:

Complex UVCB substance

IUPAC Name:

Polyethylene polyamine, pentaethylenehexamine fraction

Test material form:

liquid

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Results and discussion

In vivo

Results

Remarks on result:

probability of severe irritation

Irritant / corrosive response data:

Undiluted PEHA is moderately irritating to the eye. Direct contact might be slightly painful and would likely produce considerable conjunctivitis including a possible burn of the soft tissues. Slight corneal injury might result, but permanent damage would not be expected. There is indication from animal tests conducted that immediate and thorough washing of contaminated eyes should be effect it in preventing corneal injury and reduce the extent of conjunctival damage.
The 10% solutionin water of PEHA studied in the laboratory is only slightly irritating to the eye.

Any other information on results incl. tables

Material	Treatment	Response-Remarks
Undiluted	Unwashed	Slight pain with moderate conjunctival irritation including a slight burn with slight iritis and corneal injury. Some conjunctivitis and iritis not cleared in one week.
Undiluted	Washed with water	Moderate corneal injury and slight iritis completely subsided in one week.
10% Aqueous solution	Washed and unwashed	Slight pain and conjunctivitis subsided in 24 hours.

 

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

It was reported that direct contact might be slightly painful and would likely produce considerable conjunctivitis including a possible burn of the soft tissues. However, based on read across with TETA it cannot be excluded that PEHA is corrosive to the eye as well.