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EC number: 807-935-0 | CAS number: 1244733-77-4
Summary of percutaneous penetration of TCPP through human skin in vitro
Concentration measured [mg/ml]
Penetration into the receptor fluid after 24 h
% of dose
Maximal flux [µg/cm2/h]
Lag time [h]
Mean total absorption [%]* (SD)
* Total absorption is defined as the amount in the receptor fluid, the receptor compartment wash and skin membrane, excluding tape strips.
The mean penetration of TCPP into the receptor fluid after 24 hours was 0.39, 9.64 and 17.75 µg/cm2, for the low, mid and high dose, respectively. The mean maximal flux was 0.027, 0.602 and 0.836 µg/cm2/h, for the three doses respectively. The mean total absorption is defined as the compound related radioactivity present in the receptor fluid, the receptor compartment wash and the skin membranes (excluding tape strips). At 0.002 mg/cm2, the total absorption ranged from 17 % to 32.8%, with a mean total absorption of 22.7 %. At the mid dose of 0.1 mg/cm2, the total absorption ranged from 9.8% to 18.2%, with the mean total absorption of 13.6%. At 1 mg/cm2, the total absorption ranged from 2.3% to 5.2%, with a mean total absorption of 3.7%.
In in vitro dermal absorption studies, the amount of penetrated substances found in the receptor fluid are considered to be systemically available. The epidermis (except for the stratum corneum) and the dermis are considered as a sink, and therefore amounts found in these tissues should also be considered absorbed (SCCNFP/0750/03 Final, October 2003). Therefore, a worst case mean total absorption value of 23 % is derived from this study for exposure to "neat" TCPP. This is considered to be a reasonable worst case value since 16 of 18 individual membrane measurements taken were found to be 23% or lower.
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