Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The complex EDTA-CoH2 consist of the organic moiety EDTA, the central atom Co2+ and the protons. As protons are known to be non-sensitizing only the EDTA-Co complex must be regarded as dangerous. In general, the complex with the chelated Co2+ ion should be less sensitizing than the free Co2+ ion. Based on that and that the complex EDTA-Co has an average stability, a worst-case assessment where the EDTA-CoH2 complex dissociate in its components can be done and so a read-across is possible to free EDTA and other Co2+ compounds. The latter are known to be possible sensitizers. Most soluble cobalt (2 +) salts are classified as skin sensitizing.

Many cobalt(II) compounds and cobalt are known for the fact, that they may cause an allergic skin reaction.

The following substances are, inter alia, classified with H317: cobalt (Index number 027-001-00-9), cobalt dichloride (Index number 027-004-00-5), cobalt sulfate (Index number 027-005-00-0), cobalt sulfide (Index number 027-003-00-X), cobalt di(acetate) (Index number 027-006-00-6), cobalt dinitrate (Index number 027-009-00-2) and cobalt oxide (Index number 027-002-00-4).

Thus as a worst case approach the substance to be registered is classified accordingly as well.