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EC number: 266-942-1 | CAS number: 67701-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 August 2005 - 25 August 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Justification for read-across, see attached file.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- OECD-Guideline 402, 1987
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Tall oil
- EC Number:
- 232-304-6
- EC Name:
- Tall oil
- Cas Number:
- 8002-26-4
- Molecular formula:
- Not applicable - UVCB substance
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: A cellulose patch with the individually weighed amount of the test substance on the surfac
- Duration of exposure:
- 24h
- Doses:
- The dose was 2000 mg per kg body weight.
- No. of animals per sex per dose:
- 5 male and 5 female/dose
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- other: LD50 dermal
- Effect level:
- > 2 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50, dermal > 2000 mg /kg body weight
- Executive summary:
Aim of the study
The aim of the study was to investigate acute toxic effects of the test substance after a single dermal administration to rats.
Methods
Methods and investigations were performed in conformance with the OECD-Guideline 402, 1987 and the Directive 92/69/EEC, annex B.3.
Administration of the test substance
"CRUDE TALL OIL", was administered once dermally on an area of approximately 6.5 cm x 8 cm on the dorsal thoracal region of 5 male and 5 female Sprague Dawley rats. The dose was 2000 mg per kg body weight.
A cellulose patch with the individually weighed amount of the test substance on the surface, was applied to the test site and held in place by fixing marginally with non irritating tape.
Patch and tape were covered semi-occlusively by a dressing.
The duration of the exposure was 24 hours.
Investigations
• Body weights: before the administration, 7 and 14 days after the administration (p.a.).
• Clinical observations: at least once per day.
• Necropsy: 14 days p.a.
Results
presence of clinical signs:
- no signs
full recovery of the survivors:
- not applicable
body weights:
- inconspicuous in all males 0 - 14 d p.a.
- body weight loss in one female 0 - 7 d p.a.
- inconspicuous in all females 7 - 14 p.a. sex differences no
findings in life and post-mortem indicate:
- no toxic effects present
LD50, dermal > 2000 mg /kg body weight
Conclusion
No local or systemic toxic effects related to administration of the test substance were noted from clinical observations or post-mortem-examination at a dose of 2000 mg of the test substance per kg body weight.
No mortality occurred.
No classification of "CRUDE TALL OIL" is therefore derived from the results of this study according to the Directive 93/21/EEC.
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