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Diss Factsheets
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EC number: 256-296-9 | CAS number: 47107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 471 (Ames-Test)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Iodo-tris(triphenylphosphine)copper(I)
- EC Number:
- 454-330-9
- EC Name:
- Iodo-tris(triphenylphosphine)copper(I)
- Cas Number:
- 15709-82-7
- Molecular formula:
- Hill formula: C54H45CuIP3 CAS formula: C54H45CuIP3
- IUPAC Name:
- Iodo-tris(triphenylphosphine)copper(I)
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 219001
- Expiration date of the lot/batch: January 01 , 2004
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: dry, room temperature, closed container
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 97a, 98, 100, 102, 1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-Mix (rat, PB/NF induced)
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 2 ... 200 µg/plate
Concentration range in the main test (without metabolic activation): 2 ... 200 µg/plate - Vehicle / solvent:
- Solvent: demineralised water
- Details on test system and experimental conditions:
- Specification
species: Salmonella typhimurium L T2
strains: TA 97a, TA 98, TA 100 and TA 102, TA 1535
mutations: T A97a: his06610, TA 98: hisD3052 TA 100 and TA 1535 hisG46, TA102: hisG428, TA97, TA98 and TA100 contain uvrB; TA97, TA98, TA100 and TA102 contain pKM 101 and rfa.
Origin and Culture
Salmonella typhimurium (all strains used) were obtained from Prof. Ames and stored as stock cultures at - 80°C.
Date of arrival: June. 23rd 2001 (TA 100), Jan. 29th 2001 (TA1535) and Feb. 25th, 2002 (TA 97a, 98, 102).
Results and discussion
Test results
- Species / strain:
- other: sat TA 97a, 98, 100, 102, 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks:
- in 1st and 2nd experiment
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Remarks:
- in 1st and 2nd experiment
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation - Executive summary:
RESULTS
In both experiments, the test item didn't show mutagenic effects towards Salmonella typhimurium. A concentration-based relationship could consequently not be observed, either. The test item didn't show any signs of cytotoxicity. The test item is considered as "not mutagenic under the test conditions".
DISCUSSION
The test item is considered not mutagenic. No toxic effects could be determined.
The confirmation tests of the genotype didn't show any irregularities.
In the first experiment, the titre of two strains was lower than the demanded value. As the spontaneous revertants lay within the normal range, this was stated as uncritical. The positive controls didn't evoke as many mutations as given by Prof. Ames, but the revertants were definitely increased in comparison with the negative controls, as well as showing mutagenic potential of the diagnostic mutagenes. The number of spontaneous revertants lay lower than given in the literature by Prof. Ames; however, compared with the historical values of LAUS GmbH, they were
within the normal range. For these reasons, the result of the test is considered valid.
As the test item is poorly soluble in water and other solvents, no analytical method could be developed. Therefore the content of the test item in the test solution could not be determined and the treatments tested were given as nominal concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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