prop-2-en-1-yl (2E)-3-phenylprop-2-enoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not reported.

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been followed but not GLP.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

No details on test material, no purity, no doses/dose volume reported, limited details on test animals and no details on environmental conditions, no individual data.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

1

Reference substance name:

prop-2-en-1-yl (2E)-3-phenylprop-2-enoate

EC Number:

813-349-6

Cas Number:

56289-56-6

Molecular formula:

C12H12O2

IUPAC Name:

prop-2-en-1-yl (2E)-3-phenylprop-2-enoate

Test material form:

liquid

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: approximately 18 hours prior to treatment
- Diet: Food was replaced in cages as soon as animals received their respective doses.
- Water: Free access to water

ENVIRONMENTAL CONDITIONS
No data.

Administration / exposure

Route of administration:

other: oral intubation

Vehicle:

unchanged (no vehicle)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: All animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain.

Statistics:

LD50 values were computed by the method of Litchfield & Wilcoxon (1949).

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 520 mg/kg bw

Based on:

test mat.

95% CL:

>= 790 - <= 1 290

Mortality:

Yes, death time 4 hours - 8 days.

Clinical signs:

Scrawny appearance.

Body weight:

No data.

Gross pathology:

No data.

Applicant's summary and conclusion

Interpretation of results:

other: Acute harmful Category 4.

Remarks:

According to EU CLP (EC No. 1272/2008 and its amendments).

Conclusions:

The acute oral toxicity test showed a calculated LD50 of 1520 mg/kg bw.

Executive summary:

In this study performed equivalent to OECD TG 401 guideline without GLP, rats (5 males and 5 females) were administered with the substance. Death time was 4 hours - 8 days. Clinical signs observed was scrawny appearance. The acute oral LD50 for the substance in male and female rats was calculated to be 1520 mg/kg bw.