Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 814-509-8 | CAS number: 62132-67-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Poly alpha olefins and their respective structural analogues were not acutely toxic when administered via oral or dermal routes in several animal studies. Hence, these substances do not meet the classification and labelling criteria for acute oral or dermal toxicants as defined by CLP EU Regulation 1272/2008 (GHS aligned) criteria; therefore DNELs were not derived for these endpoints.
In the studies that concluded an LC50 of lower than 5 mg/L, deaths can be attributed entirely to chemical pneumonitis, with the primary reported effects being reported being dark red lung tissue. The concentrations required to achieve these results do not represent a realistic scenario of how PAOs would behave in normal atmospheric conditions. The key value for vapour pressure given for PAOs is 1.889 Pa. This is so low that PAOs are not expected to volatilise and thus, an acute toxicity inhalation hazard is not deemed to be relevant. Therefore, DNELs have not been derived.
Regulatory classification and labeling for aspiration toxicity relies on the measured or calculated kinematic viscosity of a substance at 40°C rather than results from toxicological studies with animals. The reported kinematic viscosity value for dec-1-ene dimers, hydrogenated is 5.1 cSt (Chevron Phillips Chemical Company, 2002). This value meets the criteria for classification as an aspiration toxicant under EU CLP (< 20.5 cSt) regulations. Dec-1-ene dimers, hydrogenated is classified as a Category 1 aspiration toxicant under EU CLP regulation 1272/2008 (GHS aligned). A DNEL is neither feasible nor appropriate for this endpoint.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Poly alpha olefins and their respective structural analogues were not acutely toxic when administered via oral or dermal routes in several animal studies. Hence, these substances do not meet the classification and labelling criteria for acute oral or dermal toxicants as defined by CLP EU Regulation 1272/2008 (GHS aligned) criteria; therefore DNELs were not derived for these endpoints.
In the studies that concluded an LC50 of lower than 5 mg/L, deaths can be attributed entirely to chemical pneumonitis, with the primary reported effects being reported being dark red lung tissue. The concentrations required to achieve these results do not represent a realistic scenario of how PAOs would behave in normal atmospheric conditions. The key value for vapour pressure given for PAOs is 1.889 Pa. This is so low that PAOs are not expected to volatilise and thus, an acute toxicity inhalation hazard is not deemed to be relevant. Therefore, DNELs have not been derived.
Regulatory classification and labeling for aspiration toxicity relies on the measured or calculated kinematic viscosity of a substance at 40°C rather than results from toxicological studies with animals. The reported kinematic viscosity value for dec-1-ene dimers, hydrogenated is 5.1 cSt (Chevron Phillips Chemical Company, 2002). This value meets the criteria for classification as an aspiration toxicant under EU CLP (< 20.5 cSt) regulations. Dec-1-ene dimers, hydrogenated is classified as a Category 1 aspiration toxicant under EU CLP regulation 1272/2008 (GHS aligned). A DNEL is neither feasible nor appropriate for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
