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EC number: 225-207-5 | CAS number: 4717-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-02-01 to 2010-02-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Fish, Acute Toxicity Test stipulated in the "Testing Methods for New Chemical Substances" of Japan
- Version / remarks:
- 2006
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Samples of all concentrations were taken at the start, before and after renewal, and at the end of exposure.
- Vehicle:
- no
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- TEST ORGANISM
- Common name: Medaka (Oryzias latipes)
- Strain: Not stated.
- Source: CERI Kurume
- Age at study initiation (mean and range, SD): 13 month.
- Length at test end (determined on control fish) (length definition, mean, range and SD): 2.3 ± 1.2 cm.
- Weight at test end (determined on control fish) (mean and range, SD): 0.11 ± 0.011 g
ACCLIMATION
- Acclimation period: 68 days.
- Acclimation conditions (same as test or not): Yes
- Type and amount of food during acclimation: Feed mixture for carp
- Feeding frequency during acclimation: Once per day. No feeding was done 24 hours before start of experiment.
- Health during acclimation (any mortality observed): No mortality was observed. - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Test temperature:
- 23.2 - 24.0°C (control)
23.4 - 24.0°C (test concentration) - pH:
- 7.4 - 7.7 (control)
7.3 - 7.6 (test concentration) - Dissolved oxygen:
- 7.3 - 8.7 (control)
7.3 - 8.7 (test concentration) - Nominal and measured concentrations:
- nominal: 0 (control) and 120 mg/L
measured: 0 (control) and 110 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 7.8 L glass tanks (diameter: 24 cm, depth: 28 cm).
- Type (delete if not applicable): Closed with teflon seat
- Aeration: No.
- Renewal rate of test solution (frequency/flow rate): After 24 hours.
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water
- Total organic carbon: 0.1 mg/L
- Particulate matter: < 1 mg/L
- Metals: Yes, all concentration < 0.0005 mg/L
- Chlorine: 14 mg/L
- Alkalinity: 35 mg/L
- Ca/mg ratio: 3.46
- Culture medium different from test medium: No.
OTHER TEST CONDITIONS
- Adjustment of pH: No.
- Photoperiod: 16-hour light / 8-hour dark
- Light intensity: Room light
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Mortality
TEST CONCENTRATIONS
- Spacing factor for test concentrations: None.
- Range finding study
- Test concentrations:
Nominal: 0 (control) and 120 mg/L
- Results used to determine the conditions for the definitive study: Yes - Reference substance (positive control):
- yes
- Remarks:
- Copper sulfate pentahydrate
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 110 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Because the mean measured test concentration is within the 20% range of nominal, the key results are based on nominal.
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
96-hour LC50: 0.54 mgfL. This value was within the stipulated range (mean ± S.D.: 0.13 - 0.96 mg/L) [mean ± S.D. : 0.55 ± 0.21 mg/L (n=44)] to background data in the laboratory. - Sublethal observations / clinical signs:
Table 1: Mortality
Mean measured concentration (mg/L)
Cumulative mortality (%)
3 hours
24 hours
48 hours
72 hours
96 hours
Control
0
0
0
0
0
110
0
0
0
0
0
Table 2: Dissolved oxygen in test solutions
Mean measured concentration (mg/L)
Dissolved oxygen (%)
Start
24 hours (old)
48 hours (old)
72 hours
End
Control
8.6
7.3
7.5
7.5
7.7
110
8.4
7.3
7.3
7.4
7.6
Table 3: pH-values in the test solutions
Mean measured concentration (mg/L)
pH-values
Start
24 hours (old)
48 hours (old)
72 hours
End
Control
7.7
7.4
7.4
7.5
7.4
110
7.7
7.3
7.5
7.5
7.4
- Validity criteria fulfilled:
- yes
- Conclusions:
- As no mortality was observed in the 120 mg/L level, the 96-hour LC50 was determined with > 120 mg/L based on nominal concentration.
- Executive summary:
The toxicity of the test item Tetrahydro-4-methyl-2H-pyran was examined in a fish acute test according to OECD 203 and under GLP conditions. Individuals of Oryzias latipes (Medaka) were exposed to 0 (control) and 120 mg/L of the test substance, equivalent to 110 mg/L mean measured concentration, for 96 hours. Concentrations were analytically verified via GC-FID. As no mortality was observed in the 120 mg/L level, the 96-hour LC50 was determined with > 120 mg/L based on nominal concentration.
Reference
Description of key information
LC50 (96-h) > 120 mg/L based on nominal concentration
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 120 mg/L
Additional information
The toxicity of the test item Tetrahydro-4-methyl-2H-pyran was examined in a fish acute test according to OECD 203 and under GLP conditions. Individuals of Oryzias latipes (Medaka) were exposed to 0 (control) and 120 mg/L of the test substance, equivalent to 110 mg/L mean measured concentration, for 96 hours. Concentrations were analytically verified via GC-FID. As no mortality was observed in the 110 mg/L level, the 96-hour LC50 was determined with > 120 mg/L based on nominal concentration.
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