Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: evaluation of available information
- Adequacy of study:
- key study
Data source
Materials and methods
Test material
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS405966. Its systemic availability after topical or oral administration is expected to be limited, because of its relatively high molecular weight (approx. 600 Da), low water solubility (< 1 mg/l) and high lipohilicity (log Pow > 6). Availability of WS405966 under a vapour state is unlikely, because of its low vapour pressure (3 x 10-5 Pa).
Based on the available data the bioacumulation potential cannot be judged. However, based on the favourable testing results, i.e. absence of adverse effects in any of the studies performed according to the REACH Regulation annexes VII and VIII, on the one hand and on the very low dermal and inhalative bioavailability of the substance (due to its physical-chemical properties) on the other hand there is no need for further investigations of a bioaccumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
