Registration Dossier
Registration Dossier
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EC number: 222-212-4 | CAS number: 3387-41-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Thuj-4(10)-ene
- EC Number:
- 222-212-4
- EC Name:
- Thuj-4(10)-ene
- Cas Number:
- 3387-41-5
- Molecular formula:
- C10H16
- IUPAC Name:
- 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexane
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- olive oil
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 2 000 mg/kg bw
- Based on:
- other: Wistar rats
- Mortality:
- Test item-related mortality in females treated with the test item in dose of 2000 mg/kg body weight was observed within the 48 hours.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423 it can be concluded that the test item Thuj-4(10)-ene is classified in Category 4 with a LD50 cut off value 2000 mg/kg body weight, after single oral administration to Wistar rats.
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