4'-Ethyl-3-fluorbiphenyl-4-boronic acid

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

03.08.06 - 18.01.07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Atm. press.:

1 013 hPa

Decomposition:

yes

Decomp. temp.:

ca. 140 °C

Two measurements in aluminium crucibles with a hole showed an endothermic effect (melting) in the temperature range 100 - 145 °C, directly followed by an exothermal decomposition in the temperature range 145- 210 °C with an energy of 130 J/g (average of two measurements). After the decomposition of the test item a further endothermic effect was observed in the temperature range 250 - 330 °C, which corresponds to the evaporation of the decomposition products. The mass loss over the measurements amounts to 84 wt. %.

Two measurements in aluminium crucibles with a hole showed an endothermic effect (melting) in the temperature range 100 - 145 °C, directly followed by an exothermal decomposition in the temperature range 145- 210 °C with an energy of 130 J/g (average of two measurements). After the decomposition of the test item a further endothermic effect was observed in the temperature range 250 - 330 °C, which corresponds to the evaporation of the decomposition products. The mass loss over the measurements amounts to 84 wt. %.

No endothermic effect was observed between the melting and the decomposition of the test item.

The test item has no boiling point under atmospheric conditions (1013 hPa). The test item decomposes directly after melting at approximately 140 °C.

An additional measurement with the capillary method was performed to clarify the results of the DSC measurements.

No	Set point	Heating rate	End point	Boiling point	Remarks
1	150 °C 295 °C	5 K/min 2 K/min	295 °C 340 °C	- -	150 °C: test item melted, yellowish, milky state 245 °C: light brown, 270 °C: Generation of gas 280 °C: partly bubbles, 295 °C: brown 300 °C: quickly bubbles, viscous, brown 310 °C: test item partly white 324 °C: test item white/brown, partly solid

According to these results and the DSC-measurements it can be stated that the test item has no boiling point at atmospheric conditions (1013.3 hPa). The test item decomposes first at approximately 140 °C. The decomposed product boiled in the temperature 300- 310 °C.

Conclusions:

The test item has no boiling point at atmospheric conditions (1013 hPa). The test item decomposes directly after melting at approximately 140°C. The decomposed product boiled in the temperature 300 -310°C.

Executive summary:

A study was conducted according to OECD test guideline 103 and Regulation (EC) No 440/2008 method A.2  to determine the boiling point of the test item using differential scanning calorimetry and capillary tube in a metal block. The test item has no boiling point at atmospheric conditions (1013 hPa). The test item decomposes directly after melting at approximately 140°C. The decomposed product boiled in the temperature 300 -310°C.

Description of key information

The test item has no boiling point at atmospheric conditions (1013 hPa).

Additional information

A study was conducted according to OECD test guideline 103 and Regulation (EC) No 440/2008 method A.2  to determine the boiling point of the test item using differential scanning calorimetry and capillary tube in a metal block.The test item has no boiling point at atmospheric conditions (1013 hPa). The test item decomposes directly after melting at approximately 140°C. The decomposed product boiled in the temperature 300 -310°C.