Registration Dossier
Registration Dossier
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EC number: 500-147-5 | CAS number: 61788-85-0 1 - 6.5 moles ethoxylated
Endpoint summary
Administrative data
Description of key information
In a limit test at 1.0 mg/L rainbow trouts were exposed for 96 hours in a static test according to OECD 203. Based on absence of mortality and signs of toxicity compared to the control, the 96 hour NOEC was determined to be 1.0 mg/L and the LC50 was >1.0 mg/L. No confirmatory analysis of the test solutions was performed due to lack of an analytical method.
Daphnids were exposed during 48 h (static test) to control, solvent control and nominal concentrations of 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L. No confirmatory analysis of the test solutions was performed due to lack of an analytical method. The EC50 is >1.0 mg/L. Based on immobility compared to the control (p <0.05) the 48h NOEC was determined to be 1.0 mg/L. Immobility in the 0.5 mg/L test concentration was significantly different (p <0.05) from the control. However, as immobility in the 1.0 mg/L test concentration was not significantly different (p <0.05) from the control, the NOEC was not affected.
In a study according to OECD 201, algae were exposed to 0, 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L (vehicle THF) of the substance during 72 hours. The highest concentration was based on the limited solubility of the substance. Effects on growth rate were seen at 1.0 mg/L, while effects on yield were observed at 0.5 mg/L. EC50 values for both growth rate and yield were > 1.0 mg/L.
Additional information
Due to the low solubility of the substance, a 1 mg/L test concentration was selected as the highest concentration based on a non-GLP range finding study in daphnia. This test concentration was also used in the other species tested. The test substance was dosed to the media via a solvent carrier (tetrahydrofuran (THF)) to assist in dosing the test compound. The concentration of solvent used in all exposure solutions and the vehicle control was 100 µL/L (with the exception of the negative control).
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