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EC number: 306-246-8 | CAS number: 96690-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Performed pre-GLP, method is described briefly (refer to the "principles of method" field)
- Principles of method if other than guideline:
- - Short description of test conditions: Dermal application of Nourypol 200 at dose levels of 0.0 (control), 3.0, 6.0 and 9.0 ml/kg body weight
- Parameters analysed / observed: growth, food and water intake and haematology, as well ass Gross examination at autopsy - GLP compliance:
- no
- Remarks:
- Prior to GLP adoption
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Soybean oil, epoxidized, Me ester, reaction products with propylene glycol
- EC Number:
- 306-246-8
- EC Name:
- Soybean oil, epoxidized, Me ester, reaction products with propylene glycol
- Cas Number:
- 96690-51-6
- IUPAC Name:
- Soybean oil, epoxidized, methyl ester, reaction products with propylene glycol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Not Specified
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Remarks:
- No further specification regarding the strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specfied
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.0 (control), 3.0, 6.0 and 9.0 ml/kg body weight
- Duration of exposure:
- Not specified
- Doses:
- 0.0 (control), 3.0, 6.0 and 9.0 ml/kg body weight
- No. of animals per sex per dose:
- Not specified
- Control animals:
- yes
- Remarks:
- The 0.0 ml/kg body weight (control) dosed group was used as control
- Details on study design:
- - Frequency of observations and weighing: Haeatological data was obtained 2 weeks after a single dermal appliaction. other observation frequencies are not specified.
- Necropsy of survivors performed: yes
- Other examinations performed: growth, food and water intake, haematology, gross examination - Statistics:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 9 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: slight skin effects at 3.0 and 6.0 ml/kg and slight to moderate skin effects at 9.0 ml/kg.
- Gross pathology:
- Gross examination at autopsy did not reveal any clearly treatment-related changes
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Based on CLP criteria
- Conclusions:
- Under the conditions of the test, the dermal LD50 was > 9 mL/kg bw (which corresponds to > 8.856 g/kg bw). Therefore, the substance does not need to be classified for acute toxicity in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
An acute dermal toxicity study with "Soybean oil, epoxidized, methyl ester, reaction products with propylene glycol" was performed in a study similar to OECD TG 402, pre-GLP, scored Klimisch 2.
"Soybean oil, epoxidized, methyl ester, reaction products with propylene glycol" was tested at 0.0 (control), 3.0, 6.0 and 9.0 ml/kg body weight in albino rabbits. Duration of observation period following administration: 14 days, growth, food and water intake, haematology and gross pathology were examined. No mortality occurred, slight skin effects were seen at 3.0 and 6.0 ml/kg and slight to moderate skin effects at 9.0 ml/kg. Gross examination at autopsy did not reveal any clearly treatment-related changes. Under the conditions of the test, the dermal LD50 was > 9 mL/kg bw (which corresponds to > 8.856 g/kg bw). Therefore, the criteria laid down in Annex I of the CLP Regulation (1272/2008/EC) are not fullfilled and the substance does not need to be classified for acute toxicity.
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