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EC number: 695-797-0 | CAS number: 93601-86-6
According to the OECD 423 test guideline the LD50 cut-off value was considered to be 500 mg/kg body weight.
The acute oral toxicity of the substance was determined in accordance with OECD 423 (2001) and according to GLP principles. The substance was administered by oral gavage to three subsequent groups of three female Wistar rats at 2000 (1 group) and 300 mg/kg body weight (2 groups). At 2000 mg/kg bw, all females were found dead or were sacrificed for ethical reasons at approx. one and a half hours after dosing on Day 1. At 300 mg/kg bw, no mortality occurred. At 2000 mg/kg bw, no clinical signs were scored in two animals which were found dead within 2 hours after dosing. One animal showed severe lethargy, cramped posture, flat posture and slow breathing on Day 1. At 300 mg/kg bw, hunched posture, uncoordinated movements and/or piloerection were noted in all animals on Days 1 and/or 2. No abnormalities were found at macroscopic post mortem examination of the animals. The acute oral toxicity (LD50) was determined to be > 300 - < 2000 mg/kg bw. Based on this result, the substance is classified for acute toxicity by the oral route (Category 4) with Harmful if swallowed (H302). According to the OECD 423 test guideline the LD50 cut-off value was considered to be 500 mg/kg body weight.
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