Registration Dossier
Registration Dossier
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EC number: 277-146-9 | CAS number: 72968-71-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Based on the acute oral discriminating dose > 10000 mg/kg bw of Macrolex Rot B and the NOAELs of 1000 mg/kg bw in the Repeated Dose 28 Day Oral Toxicity Study in Rodents and the Reproduction/ Developmental Toxicity Screening Test, no hazard is identified for systemic toxicity.
Macrolex Rot B is not irritating/corrosive to the skin and not irritating to the eyes. Based on the available phys-chem data and the LLNA results of the test item in acetone/olive oil, Macrolex Rot B is considered to exert no skin sensitizing potential. Therefore, for local effects no hazard is identified.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Based on the acute oral discriminating dose > 10000 mg/kg bw of Macrolex Rot B and the NOAELs of 1000 mg/kg bw in the Repeated Dose 28 Day Oral Toxicity Study in Rodents and the Reproduction/ Developmental Toxicity Screening Test, no hazard is identified for systemic toxicity.
Macrolex Rot B is not irritating/corrosive to the skin and not irritating to the eyes. Based on the available phys-chem data and the LLNA results of the test item in acetone/olive oil, Macrolex Rot B is considered to exert no skin sensitizing potential. Therefore, for local effects no hazard is identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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