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EC number: 200-641-8 | CAS number: 67-03-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 May 2015 to 16 July 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- Principles of method if other than guideline:
- The standard A6 Method was not applicable for this test material, due to the high indeterminable saturation levels produced in water. Therefore, the water solubility had to be estimated based on visual appraisal.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 50 - <= 55 other: % (w/w)
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 2.2
- Details on results:
- - The results of the Preliminary Test can be seen in Table 1. The water solubility of the test material was determined to be between 50.0 and 74.9% w/w at 20.0 ± 0.5 °C.
- The results of the Main Test can be seen in Table 2. The water solubility of the test material was determined to be between 49.8 and 55.0% w/w at 20.0 ± 0.5 °C.
- The standard A6 Method was not applicable for this test material, due to the high indeterminable saturation levels produced in water. Therefore, the water solubility had to be estimated based on visual appraisal.
- The water solubility of the test material has been determined to be in the range 50.0 to 55.0 % w/w at 20.0 ± 0.5 °C. The test material can therefore be classified as very soluble in water, as indicated by the European Chemicals Agency (ECHA). - Conclusions:
- Under the conditions of this study, the water solubility of the test material has been determined to be in the range 50.0 to 55.0 % w/w at 20.0 ± 0.5 °C. The test material can therefore be classified as very soluble in water, as indicated by the European Chemicals Agency (ECHA).
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions.
A preliminary test was performed in order to select the appropriate method and to determine the approximate amount of test material to be used in the main test. In the main test the samples were shaken at 30 °C for a saturation period of 72 hours. After static re-equilibration at 20 °C for a period of approximately 24 hours, the contents of the flasks were visually checked for undissolved test material.
The standard A6 Method was not applicable for this test material, due to the high indeterminable saturation levels produced in water. Therefore, the water solubility had to be estimated based on visual appraisal.
Under the conditions of this study, the water solubility of the test material has been determined to be in the range 50.0 to 55.0 % w/w at 20.0 ± 0.5 °C. The test material can therefore be classified as very soluble in water, as indicated by the European Chemicals Agency (ECHA).
Reference
Table 1: Results of the Preliminary Test
Sample |
Time Shaken at 30 °C (h) |
Time Equilibrated at 20 °C (h) |
Saturation Concentration (% w/w) |
Solution pH |
Observations |
1 |
24.3 |
24.3 |
24.8 |
2.10 |
Clear, colourless, non-viscous liquid with no visible excess of test material |
2 |
24.3 |
24.3 |
50.0 |
2.16 |
Clear, colourless, non-viscous liquid with no visible excess of test material |
3 |
24.3 |
24.3 |
74.9 |
N/A |
White, opaque, solid mass of test material. No liquid visible. |
4 |
24.3 |
24.3 |
94.4 |
N/A |
White, opaque, solid mass of test material with some loose clumps of powder. No liquid visible. |
Table 2: Results of the Main Test
Sample |
Time Shaken at 30 °C (h) |
Time Equilibrated at 20 °C (h) |
Saturation Concentration (% w/w) |
Solution pH |
Observations |
1 |
72 |
24.3 |
49.8 |
2.14 |
Clear, colourless, non-viscous liquid with no visible excess of test material |
2 |
72 |
24.3 |
55.0 |
2.19 |
Colourless liquid with a large excess of test material at the base of the flask. Approximately 1/2 of the sample volume is liquid and 1/2 is solid. |
3 |
72 |
24.3 |
59.5 |
2.22 |
Colourless liquid with a large excess of test material at the base of the flask. Approximately 1/3 of the sample volume is liquid and 2/3 is solid. |
4 |
72 |
24.3 |
64.2 |
N/A |
A few small droplets of liquid on the sides of the flask. Solid white mass of test material at the base. |
5 |
72 |
24.3 |
69.8 |
N/A |
A few small droplets of liquid on the sides of the flask. Solid white mass of test material at the base and on the sides. Some powder visible at the very bottom of the flask. |
6 |
72 |
24.3 |
73.4 |
N/A |
Solid white lumps of test material on the sides of the flask with a large white mass of test material at the base. The powder nature of the test material can be recognised. |
Description of key information
Under the conditions of this study, the water solubility of the test material has been determined to be in the range 50.0 to 55.0 % w/w at 20.0 ± 0.5 °C. The test material can therefore be classified as very soluble in water, as indicated by the European Chemicals Agency (ECHA).
Key value for chemical safety assessment
- Water solubility:
- 500 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
A preliminary test was performed in order to select the appropriate method and to determine the approximate amount of test material to be used in the main test. In the main test the samples were shaken at 30 °C for a saturation period of 72 hours. After static re-equilibration at 20 °C for a period of approximately 24 hours, the contents of the flasks were visually checked for undissolved test material.
The standard A6 Method was not applicable for this test material, due to the high indeterminable saturation levels produced in water. Therefore, the water solubility had to be estimated based on visual appraisal.
Under the conditions of this study, the water solubility of the test material has been determined to be in the range 50.0 to 55.0 % w/w at 20.0 ± 0.5 °C. The test material can therefore be classified as very soluble in water, as indicated by the European Chemicals Agency (ECHA).
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