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EC number: 232-113-8 | CAS number: 7787-41-9
See attached document below for results tables.
A GLP study was performed to assess the toxicity of Barium Selenate when administered orally. The study was performed in accordance with OECD guideline 420 following a fixed dose procedure. Initially single female rats were dosed at 50 mg/kg bw/day and 300 mg/kg bw/day. No mortality or signs of toxicity were observed at 50 mg/kg bw/day; therefore a further 4 female animals were dosed at 300 mg/kg bw/day.
The animals were observed for 14 days after dosing. All animals were subject to a gross pathological examination.
One animal died after dosing with 300 mg/kg bw/day on day 2. No clinical signs were observed in animals dosed with 50 mg/kg bw/day, animals dosed with 300 mg/kg bw/day exhibited hunched posture, piloerection, ataxia, deceased activity, pallor of the extremities and ptosis. The clinical signs developed from 2 hours after dosing up to day 7.
All surviving animals showed either no change or a decrease in body weights over the first week of the observation period, followed by a gain in body weight during the second week of observation.
No macroscopic changes were observed in the animal that died during the study, one of the surviving 4 animals dosed with 300 mg/kg bw/day showed pelvic dilation of the kidney.
Based on the results of the study, the test substance barium selenate is classified as Acute Toxicity Category 4 according to the Globally Harmonised System of Classification of Chemicals.
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