Registration Dossier
Registration Dossier
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EC number: 813-788-3 | CAS number: 1803551-73-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- no guideline followed
- Version / remarks:
- The log Pow was estimated by comparing the water and the 1-octanol solubility of the test item.
- Principles of method if other than guideline:
- The determination of the partition coefficient of RFR 6634 was determined by comparing the water solubility of the test item with data on the 1-octanol solubility.
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Date of receipt: 2017-04-19
Expiry date: 2018-09-14 - Analytical method:
- other: visual inspection
- Type:
- Pow
- Partition coefficient:
- < 1
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: The pH value is assumed and was not determined.
- Remarks:
- RFR 6634 is better solvable in water than in 1-octanol.
- Type:
- log Pow
- Partition coefficient:
- < 0
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: The pH value is assumed and was not determined.
- Remarks:
- RFR 6634 is better solvable in water than in 1-octanol.
- Conclusions:
- Tloe log Pow was determined to be < 0.
- Executive summary:
The water solubility of RFR 6634 was determined to be > 100 g/L due to visual inspection of a 1:10 mixture of RFR 6634 and water. A 1:1 mixture of RFR 6634 resulted in a slightly turbid but still liquid mixture. Pretests with regard to the 1-octanol solubility of RFR 6634 revealed a similarly high solubility of the test item in octanol, as 100 mg were dissolvable in 0.4 mL of 1-octanol. However, a 1:1 mixture (test item/octanol) was still a solid, demonstrating that the test item was not solvable in water at this ratio. Accordingly, RFR 6634 was better solvable in water in comparison to 1-octanol. The logPow was determined by estimating the ratio of the water and the octanol solubility.
Accordingly, the log Pow was determined to be < 0.
Reference
Description of key information
The water solubility of RFR 6634 was determined to be > 100 g/L due to visual inspection of a 1:10 mixture of RFR 6634 and water. A 1:1 mixture of RFR 6634 resulted in a slightly turbid but still liquid mixture. Pretests with regard to the 1-octanol solubility of RFR 6634 revealed a similarly high solubility of the test item in octanol, as 100 mg were dissolvable in 0.4 mL of 1-octanol. However, a 1:1 mixture (test item/octanol) was still a solid, demonstrating that the test item was not solvable in water at this ratio. Accordingly, RFR 6634 was better solvable in water in comparison to 1-octanol. The logPow was determined by estimating the ratio of the water and the octanol solubility.
Accordingly, the log Pow was determined to be < 0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0
- at the temperature of:
- 20 °C
Additional information
0 should read: < 0.
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