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Short-term toxicity to aquatic invertebrates

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short-term toxicity to aquatic invertebrates
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur
Reason / purpose:
data waiving: supporting information
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
according to
other: DIN 38412 Part 11, Daphnia- Short term test
GLP compliance:
not specified
Analytical monitoring:
Test organisms (species):
Daphnia magna
Test type:
Water media type:
Limit test:
Total exposure duration:
24 h
Key result
24 h
Dose descriptor:
Effect conc.:
> 10 000 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
Validity criteria fulfilled:
The 24h EC50, flow though method, tesed on Daphnia magna was > 10000 mg/l for 2-propanol

Description of key information

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
10 000 mg/L

Additional information

No studies were conducted on the target substance. The target substance is hydrolytically unstable that, when coming into contact with water, it rapidly hydrolyzs to form 2-propanol, isostearic aicd and insoluble titanium dioxide. Therefore, the intrinsic toxicity of the target substance lies in the hydrolysis products.

The titanium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.

Isostearic acid has very low water solubility (c.a. 0.597 mg/l at 20°C) and therefore exposure to the isostearic acid is unlikely.

2-propanol is practically miscible with water and therefore is taken into consideration. The 24h EC50 to Daphnia magna was > 10000 mg/l (Bringmann and Kühn, 1977). This value is used for CSA evaluation.