Reaction mass of 2-amino-2-methyl-1-propanol hydrochlorid (3207-12-3) and 2-amino-2-methyl-1-propanol (124-68-5)

Appearance / physical state / colour

Administrative data

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 April 2018 to 26 April 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

>= -30 - <= -16 °C

Atm. press.:

1 013.25 hPa

Decomposition:

no

Sublimation:

no

Preliminary Test

Since the test item is a liquid at ambient temperature a preliminary test was conducted. The freezing point of the test item was determined to be below -20 °C. Thus, main study was conducted.

 

Main Test

The crucibles were cooled down from ambient temperature to -40 °C with a constant cooling rate of 10 K/min under an inert atmosphere. After a waiting period of 30 min at -40 °C, the temperature was increased up to room temperature at a constant heating rate of 10 K/min. In the temperature range of - 30 °C to -16 °C, an endothermic reaction was observed, which was related to the transition from the solid to liquid phase.Thus, the melting point of the test item was determined to be in range from -30 to -16 °C.

Conclusions:

The melting point of the test item was determined to be in range from -30 to -16 °C.

Executive summary:

A study was conducted according to OECD test guideline 102, Regulation (EC) No 440/2008 method A.1 and EPA OCSPP test guideline 830.7200 to determine the melting point of the test item using differential scanning calorimetry. The test item was weighed out into an aluminium crucible under an inert atmosphere (nitrogen). Two tests with 7.5 mg and 7.6 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. The substance is a liquid at ambient conditions. Therefore the crucibles were cooled down from ambient temperature to -40 °C with a constant cooling rate of 10 K/min under an inert atmosphere. After a waiting period of 30 min at -40 °C, the temperature was increased up to room temperature at a constant heating rate of 10 K/min. In the temperature range of - 30 °C to -16 °C, an endothermic reaction was observed, which was related to the transition from the solid to liquid phase.Thus, the melting point of the test item was determined to be in range from -30 to -16 °C.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Materials and methods

Test guideline

Qualifier:

no guideline required

GLP compliance:

no

Test material

Test material information

1

Reference substance name:

(2-hydroxy-1,1-dimethylethyl)ammonium chloride

EC Number:

221-713-5

EC Name:

(2-hydroxy-1,1-dimethylethyl)ammonium chloride

Cas Number:

3207-12-3

Molecular formula:

C4H11NO.ClH

IUPAC Name:

1-hydroxy-2-methylpropan-2-aminium chloride

Test material form:

liquid

Results and discussion

Physical state at 20°C and 1013 hPa:

liquid

Form / colour / odour

Key result

Form:

other: paste

Colour:

Clear yellowish

Substance type:

organic

Applicant's summary and conclusion

Conclusions:

The test item is a clear yellowith paste (liquid) at 20 °C and 1013.25 hPa.