Registration Dossier
Registration Dossier
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EC number: 224-116-8 | CAS number: 4203-89-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR predictions were used for skin sensitization. The criteria listed in Annex XI of Regulation No. 1907/2006 are considered to be adequately fulfilled and therefore, the endpoint sufficiently covered and suitable for risk assessment.
Data source
Reference
- Reference Type:
- other: QSARs
- Title:
- QSARs
- Author:
- AkzoNobel
- Year:
- 2 018
- Bibliographic source:
- QSAR Toolbox DART Scheme v.1.2; Derek Nexus v.6.0.1; VEGA - Developmental/Reproductive Toxicity library (PG), v.1.0.0)
Materials and methods
- Principles of method if other than guideline:
- QSAR
- Justification for non-LLNA method:
- QSAR
Test material
- Reference substance name:
- 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate
- EC Number:
- 224-116-8
- EC Name:
- 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate
- Cas Number:
- 4203-89-8
- Molecular formula:
- C14H23NO3
- IUPAC Name:
- 2-{1-oxa-4-azaspiro[4.5]decan-4-yl}ethyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Based on QSAR predictive analysis, the substance is considered to be a skin sensitizer, Cat 1
- Executive summary:
Based on QSAR predictive analysis using four well known models (DEREK Nexus v.6.0.1; Biovia Discovery Studio 2018 (TOPKAT); VEGA-QSAR v.1.1.4; and OECD QSAR Toolbox, v. 4.2) the substance is considered to be a skin sensitizer, Cat 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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