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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1967
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
No CoA, pre-GLP, only males, limited information on animals and conditions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
performed pre-GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis-sec-butyl peroxydicarbonate
EC Number:
243-424-3
EC Name:
Bis-sec-butyl peroxydicarbonate
Cas Number:
19910-65-7
Molecular formula:
C10H18O6
IUPAC Name:
2,2'-[dioxybis(carbonyloxy)]dibutane
additive 1
Reference substance name:
Naphtha (petroleum), hydrotreated heavy
EC Number:
265-150-3
EC Name:
Naphtha (petroleum), hydrotreated heavy
Cas Number:
64742-48-9
Molecular formula:
UVCB
IUPAC Name:
Naphtha (petroleum), hydrotreated heavy
Test material form:
liquid
Details on test material:
Clear liquid

Test animals

Species:
rat
Strain:
other: Charles River CD
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: no data
- Females (if applicable) nulliparous and non-pregnant: not applicable
- Age at study initiation: no data
- Weight at study initiation: 151-186 grams
- Fasting period before study: yes
- Housing: metal cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

IN-LIFE DATES: From: To: no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: odorless mineral spirits
Details on oral exposure:
VEHICLE: odorless mineral spirits

MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg

DOSAGE PREPARATION (if unusual):
D-225 was maintained at -18C (0 Fahrenheit) until administered, at which time these were permitted to warm to a temperature of 10C (50 Fahrenheit) prior to dosing. The equipment used to administer these compounds (syringes, needles, beakers and diluent) were chilled to 10C (50 Fahrenheit) prior to use. Immediately after administering these compounds they were destroyed in accordance with the sponsor's instructions.
Doses:
100, 215, 464, 1000, 2150, 4640 mg/kg
No. of animals per sex per dose:
5 males
Control animals:
yes
Remarks:
vehicle controls
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: none
Statistics:
none

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 4 640 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no mortalities occured
Mortality:
none
Clinical signs:
other: no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 > 4640 mg/kg bw, no mortalities
Executive summary:

LD50 > 4640 mg/kg bw, no mortalities