Registration Dossier
Registration Dossier
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EC number: 204-854-7 | CAS number: 127-65-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other (measured): Akzo Nobel RCD internal procedure
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.3
- Temp.:
- 20 °C
- pH:
- 9.4
- Details on results:
- Before extraction: 25.0 g Chloramine-T (assay 99.3%) in 250.0 ml H20 results in a 9.32 w t % Chloramine-T solution. After extraction: 8.85 w t % Chloramine-T in the water-layer -> 0.47 wt % Chloramine-T in the octanol-layer. Partition coefficient: (20ºC) K oct/water = 0.47/8.85 = 0.05. Log Koc/water = -1.30. The experiment was done in duplo: both experiments gave the same result.
- Conclusions:
- Log Koc/water = -1.30.
- Executive summary:
According to an Akzo Nobel inhouse method the partitioning coefficient was determined for Tosylchloramide sodium. Substance (25.00 g, assay 99.38%) was dissolved at 20% in demineralized water (250.0 ml). 1-Octanol (250.0 ml) was added after the Tosylchloramide sodium had been dissolved completely. The two-layer system formed was stirred vigorously for 15 minutes at 20ºC. The entire solvent mixture was transferred to a separation funnel. Separation took place and the concentration of Tosylchloramide sodium in the water-layer was determined. The experiment was done in duplo. Before extraction: 25.0 g Tosylchloramide sodium (assay 99.3%) in 250.0 ml H20 results in a 9.32 w t % Tosylchloramide sodium solution. After extraction: 8.85 w t % Tosylchloramide sodium in the water-layer -> 0.47 wt % Tosylchloramide sodium in the octanol-layer. Partition coefficient: (20ºC) K oct/water = 0.47/8.85 = 0.05. Log Koc/water = -1.30. The experiment was done in duplo: both experiments gave the same result.
Reference
Description of key information
Tosylchloramide sodium, trihydrate has a Partition coefficient: (20ºC) K oct/water = 0.47/8.85 = 0.05. Log Koc/water = -1.30
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.3
- at the temperature of:
- 20 °C
Additional information
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