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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: adopted according to OECD SIDS, peer reviewed data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 003
- Reference Type:
- study report
- Title:
- Unnamed
- Reference Type:
- publication
- Title:
- No information
- Author:
- Nair RS, Johannsen FR, Schroeder RE (1985) Evaluation of|Teratogenic Potential of Para-Nitroaniline and|Para-Nitrochlorobenzene in Rats and Rabbits. In: Toxicity of|Nitroaromatic Compounds (Rickert, D.E. ed.): pp. 61-85,|Hemisphere Publishing Corporation, New York
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- Method: other: according to OECD Guide-line 414: 24 mated rats per group, see also freetoxt ME
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: > 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- days 6-19 of gestation
- Frequency of treatment:
- daily
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sex: female
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 5 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 15 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Maternal data:
Pregnancy rates were similar between the groups. No
mortality occurred in the control or treated groups during
d6-20. Terminal body weight and body weight gain (d6-20) was
comparable between control, low- and mid-dose females, but
sign. reduced in high-dose females (71 g versus 118 g of
controls). Several high-dose females were reported to have
pale eye color during dosing interval. Comparable between
control, low- mid- and high-dose groups were the mean
numbers of implantations (13.3,13.9,14.1,13.6), but mean
number of resorptions were sign. increased in the high-dose
group: 5.6 versus 0.5 in controls and mean number of live
fetuses were significant decreased (8.0 versus 12.8 in
controls) in this dose-group, 7/22 high-dose females (31.8%)
had uterine implantation sites comprised entirely of
resorption sites.
Maternal gross postmortem observations: mean spleen weights
sign. higher than control in each treated group, mean spleen
to body weight ratio higher in all treated groups, sign. in
the mid- and high-dose group (dose-related increase), from
low-dose onwards significant dose-dependent lesions of the
spleen: enlargement (up to 4 x normal size in high-dosed
females), dark coloration and/or pitted surface.
Fetal data:
The mean number of male and female fetuses and mean fetal
weights were comparable between the control, low- and
mid-dose groups. In the high dose group, the mean number of
male and female fetuses (male: 4.2 versus 6.2 in control,
female 3.8 versus 5.5 in contr.) and the respective mean
weights (male: 3.33 g versus 3.95 g, female: 3.11 g versus
3.76 g in contr.) were markedly lowered. In this dose-group
the incidence of ossification variations (i.e.,
assymetrical/unossified sternebrae, incompletely ossified
cervical vertebral transverse processes, rudimentary
structures) was sign. increased when compared to controls
(95.7 % versus 85.5 % in contr.).
Fetal evaluations at low- and mid-dose levels did not reveal
a teratogenic response. At high-dose level, a significant
increase in the incidence of skeletal malformations (30.4 %
versus 1.3 % in controls), predominantly angulated ribs
alone or associated with misshapen and/or shortend bones of
the forelimbs (i.e. humerus, radius, ulna) was noted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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