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Diss Factsheets
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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Endpoint summary
Administrative data
Description of key information
p-chloronitrobenzene was found to be a sensitizer
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
- Principles of method if other than guideline:
- 3 drops of a 1 % solution to the clipped area of the skin for 5 d; on d7 1 drop of the 1 % solution to an untreated area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Draize test
- Justification for non-LLNA method:
- modified Draize test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: epicutaneous, 1% solution in aceton
- Vehicle:
- other: acetone
- Concentration / amount:
- 1%
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 1%
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 1 % 2nd application: Challenge 1 %
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- Remarks on result:
- not measured/tested
- Reading:
- 2nd reading
- Group:
- test chemical
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication/study report which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 3 drops (10 % sol.) to the clipped area of the skin; 22nd day inj. of Freund-adjuvans and TS into the hind paw (0.5 mg/kg bw), d28 1 drop (10 % sol.) to an untreated clipped area of the skin; reading time not mentioned
- GLP compliance:
- no
- Type of study:
- other: modified Freunds complete adjuvant test
- Justification for non-LLNA method:
- modified Freunds complete adjuvant test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
- Day(s)/duration:
- Not available
- Adequacy of induction:
- not specified
- Route:
- other: epicutaneous, no more informations
- Vehicle:
- other: acetone
- Concentration / amount:
- 10% in acetone
- No. of animals per dose:
- 10
- Details on study design:
- 1st application: Induction 10 % 2nd application: Challenge 10 %
- Positive control substance(s):
- not specified
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- N/A
- Remarks on result:
- not measured/tested
- Reading:
- 2nd reading
- Group:
- test chemical
- Dose level:
- N/A
- Remarks on result:
- not measured/tested
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
Referenceopen allclose all
No more data given
No more data given
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In an acceptable, well-documented publication which meets basic scientific principles the skin sensitisation potential of 1 -chloro-2 -nitrobenzene was investigated. The study was performed in guinea pigs with 3 drops of a 10% solution to a clipped area of the skin. On the 22nd day Freund-adjuvans was injected with the test substance into the hind paw (0.5 mg/kg bw). 28 days after the first administration 3 drops of the 10 % solution were applied to an untreated clipped area of the skin. The test substance induce sensitisation reactions in 50% of the tested animals.There is sufficient evidence that 1 -chloro-4 -nitrobenzene has a sensitisation potential (Rusakov et al., 1973).
A further indicator to a sensitisation potential of 1 -chloro-4 –nitrobenzene is the comparable chemical structure to the typical sensitizer 2,4-dinitrochlorobenzene. The allergenic activity of p-chloronitrobenzene is less marked than that of 2,4-dinitrochlorobenzene but p-chloronitrobenzene provokes stronger sensitiation effects than o-chloronitrobenzene.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Classification:
DSD: Xi, R43. May cause sensitisation by skin contact.
EU-GHS: Skin Sensitisation Category 1. May cause an allergic skin reaction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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