N-acetylhexanelactam

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

N-acetylhexanelactam

EC Number:

217-565-6

EC Name:

N-acetylhexanelactam

Cas Number:

1888-91-1

Molecular formula:

C8H13NO2

IUPAC Name:

1-acetylazepan-2-one

Test material form:

liquid

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Details on test organisms:

Danio rerio (HAMIL TON-BUCHANAN)
Breeding at test facility
mean length: 3.0 cm (2.8-3.2 cm)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Test conditions

Test temperature:

21.4-21.6°C

pH:

7.2-7.9

Dissolved oxygen:

5.8-9.3

Nominal and measured concentrations:

0, 1000 mg/L

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

1 000 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Effect concentrations 2

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Details on results:

In the control and the limit concentration of 1000 mg/L no mortality occured. Exposed fish showed symptoms.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The acute fish toxicity of the registration substance was tested in a study according to OECD203 resulting in a NOEC (96h) of 1000 mg/L and a LC50 (96h)>1000mg/L.

Executive summary:

The acute fish toxicity of the registration substance was tested in a study according to OECD203 resulting in a NOEC (96h) of 1000 mg/L and a LC50 (96h)>1000mg/L.