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EC number: 287-947-5 | CAS number: 85631-00-1
In this study Stimulation Indices of 12.73, 18.20, and 30.66 were determined with the test item at concentrations of 0.25, 0.5, and 1% in MEK. The EC3 value could not be calculated, since all obtained SI´s were above the threshold value of 3.
In the study the test item LA-63P formulated in MEK (methyl ethyl ketone) was assessed for its possible skin sensitising potential.
For this purpose a local lymph node assay was performed using test item concentrations of 0.25, 0.5, and 1%. The highest concentration tested was the highest concentration that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation as confirmed by three pre-experiments.
The animals did not show any signs of systemic toxicity during the course of the study and no cases of mortality were observed. From day 2 to 4, the animals treated with a test item concentration of 0.5 and 1% showed an erythema of the ear skin (Score 1, see Appendix 3 for details). Animals treated with 0.25% test item concentration did not show any signs of local skin irritation.
In this study Stimulation Indices (S.I.) of 12.73, 18.20, and 30.66 were determined with the test item at concentrations of 0.25, 0.5, and 1% in MEK, respectively.
The test item LA-63P was found to be a skin sensitiser. An EC3 value could not be derived, since all tested concentrations induced an S.I. value greater than the threshold value of 3.
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