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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 January 2014 - 04 June 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 11063
- Expiration date of the lot/batch: 310 December 2014

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 6.2
Temp.:
25 °C
Remarks on result:
not measured/tested
Remarks:
pH is not provided
Details on results:
It was evident that all components of the reference mixture eluted before the significant components of the test substance under the test conditions, with the last standard (DDT, known log10Pow = 6.2) eluting after approximately 3 minutes. A value of log10Pow for ADK STAB LA-63P of greater than 6.2 was thus obtained.
Conclusions:
ADK STAB LA-63P was found to have a log10Pow value of greater than 6.2.

Description of key information

ADK STAB LA-63P was found to have a log10Pow value of greater than 6.2.

Key value for chemical safety assessment

Log Kow (Log Pow):
6.2
at the temperature of:
25 °C

Additional information