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EC number: 231-185-8 | CAS number: 7443-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate p. a.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.68 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % confidence limits: 1.38 - 2.05 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the nominal concentrations ( measured >80%) of the test item, the following results were obtained: EC50 (48 h) = 1.68 mg/L, NOEC (48 h) = 1.25 mg/L and LOEC (48 h) = 2.50 mg/L.
- Executive summary:
In the acute immobilization test with Daphnia magna (STRAUS) the effects of the test item Hostavin PR-25 GR were determined according to OECD 202 (2004).Based on the measured concentrations ( measured >80%) of the test item, the 48 -h EC50 for Daphnia magna was estimated to be 1.68 mg/L (95 % confidence limits: 1.38 - 2.05 mg/L). The NOEC after 48 h was determined to be 1.25 mg/L as the highest tested concentration with no biologically significant effect (Immobilization rates of ≤ 10 % are seen to be not significant according to the guideline). The LOEC after 48 h was determined to be 2.50 mg/L as the lowest tested concentration with a biologically significant effect (Immobilization rates of > 10 % are seen to be significant according to the guideline).
Reference
Description of key information
48h-EC50 (Daphnia magna, immobilisation) = 1.68 mg/L, 48h-NOEC (Daphnia magna, immobilisation) = 1.25 mg/L; 48h-LOEC (Daphnia magna, immobilisation) = 2.50 mg/L (nominal, OECD 202, 2011)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.68 mg/L
Additional information
In a reliable key study, acute immobilisation of Daphnia magna caused by the submission substance was determined according to OECD 202 (2004) and in compliance with GLP (RL1). The study was conducted with five test concentrations (nominal 10, 5, 2.50, 1.25, 0.625 mg/L) under static test conditions during 48 hours. A control was run in parallel. The test concentrations and control were analytically verified by HPLC-DAD analysis. Derived effect concentrations were based on nominal test concentration. Observed effects followed a dose-response relationship with no effect at the lowest test concentration (0.625 mg/L), first occurrence of immobilisation at 1.25 mg/L and complete immobilisation at highest tests concentration (10 mg/L). Derived effect concentrations were: 48h-EC50 = 1.68 mg/L (95 % confidence limits: 1.38 - 2.05 mg/L), 48h-NOEC = 1.25 mg/L and 48h-LOEC = 2.50 mg/L. The study was considered reliable and adequate for the environmental hazard assessment for aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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