1-Propanaminium, 3-amino-N-ethyl-N,N-dimethyl-, N-rape-oil acyl derivs., Et sulfates

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From July 14, 2017 to November 13, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

not specified

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

ca. 17.1 - ca. 17.7 °C

Atm. press.:

ca. 101.3 kPa

Decomposition:

no

Key result

Melting / freezing pt.:

ca. 141.4 - ca. 141.5 °C

Atm. press.:

ca. 101.3 kPa

Decomposition:

no

Results

Mass Used: 2.85 mg (test F), 4.55 mg (test G)

Crucible Type: Aluminium (open lid)

Temperature Range: 0°C – 200°C

Ramp Rate: 1 K.min-1

Test Atmosphere: Nitrogen

	1^stEndotherm	2^ndEndotherm	3^rdEndotherm	4^thEndotherm
	Run 1 (F)
Endotherm onset temperature (°C)	17.65	141.45	186.44	191.38
	Run 2 (G)
Endotherm onset temperature (°C)	17.11	141.38	185.83	191.54

Melting Range 1: 17.1 – 17.7°C

Melting Range 2: 141.4 – 141.5°C

Comment

From a subsequent observation seen in a Mettler Toledo capillary melting point apparatus, the endotherm in the region of 180 – 200°C is due to a boiling event. It was also noted that at approximately 115°C the opaque sample became a clear liquid. This could be due to the melting or solubilisation for a subcomponent present in the sample and may correspond to the second melting point observed in the DSC. The product is known to be of Unknown or Variable Composition, Complex Reaction Products and Biological Materials (UVCB Substance), consequently the presence of multiple boiling or melting point events in a DSC trace is not unexpected.

Conclusions:

Under the study conditions, the melting point range of the test substance was identified to be quiet broad 17.1 - 141.5°C at 101.3 kPa, due to melting of different chemical components at different temperatures.

Executive summary:

A study was conducted to determine the melting point of the test substance, using the Differential Scanning Calorimetry (DSC) method, according to EU Method A1 and OECD Guideline 102, in compliance with GLP. Two melting ranges were determined for the test substance, i.e., first range as: 17.1 - 17.7°C and the second range as: 141.4 - 141.5°C at 101.3 kPa. Identification of multiple melting/boiling point ranges were not considered unexpected by the study authors, given the UVCB nature of the test substance. It was also noted that at approximately 141°C the opaque sample became a clear liquid. This could be due to the melting or solubilisation for a subcomponent present in the sample and may correspond to the second melting point observed in the DSC. Therefore, under the study conditions, the melting point range of the test substance was identified to be quiet broad 17.1 - 141.5°C at 101.3 kPa, due to melting of different chemical components at different temperatures (Chilworth, 2017).

Description of key information

The melting point of the test substance was determined using the Differential Scanning Calorimetry (DSC) method according to EU Method A1 and OECD Guideline 102 (Chilworth, 2017).

Additional information

Two melting point ranges were determined, given the UVCB nature of the test substance: first range: 17.1 - 17.7°C; second range: 141.4 – 141.5°C at 101.3 kPa (due to melting of different chemical components at different temperatures).