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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 13, 1997 - February 5, 1998
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998
Report date:
1998

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Reference substance name:
SP 6012
IUPAC Name:
SP 6012
Details on test material:
See attached study report for details

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female
Details on test animals or test system and environmental conditions:
See attached study report for details

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
See attached study report for details
Duration of exposure:
1, 2.5, 4 hours, and 14 day observations. See attached study report for details.
Doses:
5,000 mg/kg bw (single dose)
No. of animals per sex per dose:
5 males/ 5 females per single dose level
Control animals:
not required
Details on study design:
See attached study report for details
Statistics:
None required for study

Results and discussion

Preliminary study:
LD50 > 5000 mg/kg bw
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
No deaths occurred during the course of the study
Clinical signs:
other: Test material produced moderate to severe dermal irritation
Gross pathology:
See attached study report for details
Other findings:
See attached study report for details

Any other information on results incl. tables

See attached study report for details

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
Estimated dermal LD50 for males and females is > 5,000 mg/kg bw
Executive summary:

See attached study report for details