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EC number: 247-665-5
CAS number: 26401-86-5
The target substance Triisooctyl 2,2’,2”-[(octylstannylidyne)tris(thio)]
triacetate (MOTI) (EC Number 247-665-5 and CAS 26401-86-5) is a
mono-constituent organotin substance that consists of a tin as central
metal element with one octyl-ligands. The source substances Octyltin
tris(2-ethylhexylmercaptoacetate (MOTE) (EC Number 248-227-6 and CAS No
27107-89-7) is also an organotin compound that has the identical
structure elements as the target substance in respect of the tin-alkyl
moiety. In addition they are isomers differing only slightly in the
structure of the C-8 alcohol of the mercaptoester ligand.
According to WHO IPCS CIRCAD (2006) organotin compounds are
characterized by a tin–carbon bond and have the general formula
RxSn(L)(4−x), where R is an organic alkyl or aryl group and L is an
organic (or sometimes inorganic) ligand. The organotin moiety is
significant toxicologically. The anionic ligand influences
physicochemical properties but generally has little or no effect on the
Since the target substance and the source substances share the identical
organotin moiety, and the organotin moiety is generally recognized as
the relevant toxophore of organotins and the toxicity estimates (AE)
respectively toxicity limits for organotins are expressed as tin, the
overall ecotoxicity/systemic toxicity of the target can be interpolated by assessing the (eco-)toxicity of the source
(WHO IPCS CIRCAD, 2006, BAUA AGS TRGS 900, 2014, Summer KH, Klein D and
Greim H, 2003).
The purity of the source and target substance are expected to be
similar, based on the manufacturing method. The impurity profile is not
expected to have strong effects on substance properties and any impurity
of (eco-)toxicological relevance of the source substances is expected to
be present in the target substance. Consequently, the hazard profiles of
the source substances, including those of their impurities, are
intrinsically covered. Differences in impurities are not expected and
thus do not have an impact on the (eco-)toxic properties.
The result of the simulated gastric hydrolysis study on our substance
shows close similarities with the hydrolysis study conducted on MOTE, in
that both materials are expected to breakdown to form the monochloride
versions of the substance as the only breakdown products, which further
backs up their similarities and the read across.
BAUA (Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (Federal
Institute for Occupational Safety and Health)) AGS (Ausschuss für
Gefahrstoffe (Committee on Hazardous Substances)) TRGS (Technical Rules
for Hazardous Substances) 900 (2014). Begründung zu
n-Octylzinnverbindungen, April 2014.
Summer KH, Klein D, Griem H (2003). Ecological and toxicological aspects
of mono- and disubstituted methyl-, butyl-, octyl-, and dodecyltin
compounds - Update 2002. GSF National Research Center for Environment
and Health, Neuherberg, for the Organotin Environmental Programme
World Health Organization (WHO) International Programme on Chemical
Safety (IPCS) Concise International Chemical Assessment Document (CICAD)
73 Mono- and disubstituted methyltin, butyltin, and octyltin compounds
(2006). Published under the joint sponsorship of the United Nations
Environment Programme, the International Labour Organization, and the
World Health Organization, and produced within the framework of the
Inter-Organization Programme for the Sound Management of Chemicals.
World Health Organization ISBN 978 92 4 153073.
Based on read-across to structurally similar substance: Octyltin
tris(2-ethylhexylmercaptoacetate) (MOTE) (CAS No 27107-89-7) which is an
isomer differing only slightly in the structure of the C-8 alcohol of
the mercaptoester ligand, it is expected MOTI is not readily
biodegradable and is not anticipated to be bioaccumulative based on a
BCF test. The ecotoxicity results are as follows:
Fish: LC50 (96h) > 100 mg/L (WSF)
Algae: ErC50 (72h) > 100 mg/L (WSF)
Daphnia: EC50 (48h): 25.80 mg/L
The chronic classification was performed based on acute data as no
chronic data (except algal NOEC) were available.
Based on the results of acute toxicity to daphnia study and the lack of
ready biodegradability of the substance, according to CLP classification
criteria the substance is classified Aquatic Chronic Category 3 – H412:
Harmful to aquatic life with long lasting effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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