Registration Dossier

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February- April 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report Date:
2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Version / remarks:
1981
Deviations:
not specified
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
Test item: (N-Cyclohexyl-diazeniumdioxy)-potassium
IUPAC name: Cyclohexylhydroxydiazene 1-oxide, potassium salt
Chemical name: Cyclohexylhydroxydiazene 1-oxide, potassium salt; synonyma: (N-Cyclohexyl-diazeniumdioxy)-potassium, K-HDO, K-NCH, Xyligen K powder, Xyligen K
Molecular formula: C6 H11 K N2 O2
Molecular mass: 182.27
Specific details on test material used for the study:
Method:
The determination was carried out in accordance with the OECD GUIDELINE FOR TESTING of CHEMICALS, 112 (1981): "Dissociation Constants in Water" and the monograph cited therein: A. Albert, E.P. Serjeant, Determination of Ionization Constants, chapter 2: Determination of ionization constants by potentiometric titration using a glass electrode, Chapman and Hall, London (1984).

Results and discussion

Dissociating properties:
yes
Dissociation constant
pKa:
5.33
Temp.:
23 °C

Applicant's summary and conclusion

Conclusions:
pKA = 5.33
Executive summary:

The measurement of the dissociation constant (PKA) of the test item at 23 °C using a test item concentration of about 0.0005 mol/L resulted in the following value: pKA = 5.33 ± 0.02. The measurement uncertainty corresponds to the triple standard deviation.