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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2003
Report Date:
2003
Reference Type:
review article or handbook
Title:
Wasserstoffperoxid
Author:
Deutsche Forschungsgemeinschaft (DFG). Senatskommission zur Prüfung gesundheistschädlicher Arbeitsstoffe
Year:
2006
Bibliographic source:
Wiley Online Library. The MAK Collection for Occupational Health and Safety.
Report Date:
2006
Reference Type:
review article or handbook
Title:
Human Health Tier II assessment for hydrogen peroxide (H2O2)
Author:
National Industrial Chemicals Notification and Assessment Scheme (NICNAS). Australian Government. Department of Health.
Year:
2018
Bibliographic source:
https://www.nicnas.gov.au/chemical-information
Report Date:
2018
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report Date:
1951

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Determination of acute oral and intravenous toxicity
GLP compliance:
no
Remarks:
pre-GLP study
Test type:
other: dilutions tested, but otherwise not speciified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
CAS numer: 7722-84-1
Purity: not stated
Concentration: 90%

Test animals

Species:
rabbit
Strain:
not specified

Administration / exposure

Doses:
not specified
No. of animals per sex per dose:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
rabbit
Effect level:
700 mg/kg bw
Based on:
test mat.
Key result
Sex:
not specified
Dose descriptor:
LD50
Remarks:
rat
Effect level:
5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
The acute oral and dermal toxicity of 90% hydrogen peroxide and dilutions thereof were examined in several species. The rabbit was the most sensitive species with a dermal LD50 of 700 mg/kg bw. The rat was the less sensitive species with a dermal LD50 of 5000 mg/kg bw.
Executive summary:

The acute oral and dermal toxicity of 90% hydrogen peroxide and dilutions thereof were examined in several species. The rabbit was the most sensitive species with a dermal LD50 of 700 mg/kg bw. The rat was the less sensitive species with a dermal LD50 of 5000 mg/kg bw (Hrubetz et al. 1951).