Registration Dossier
Registration Dossier
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EC number: 233-482-8 | CAS number: 10193-99-4
Endpoint summary
Administrative data
Description of key information
Based on read across from PETMP, PETMA is assumed to be harmful if swallowed (LD50 = 1500 mg/kg bw) and non-toxic if inhaled (no mortality at highest attainable concentration).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- see category report attached as "full study report"
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- read across from PETMP using OECD QSAR Toolbox 4.2 using Structural Similarity as descriptor
- Species:
- rat
- Route of administration:
- oral: gavage
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 1 500 mg/kg bw
- Based on:
- act. ingr.
- Remarks:
- read across from PETMP
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on read across from PETMP, PETMA is classified as Acute Tox 4 - H302
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 500 mg/kg bw
- Quality of whole database:
- read across from valid study
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- see category report attached as "full study report"
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- read across from PETMP using OECD QSAR Toolbox 4.2 using Structural Similarity as descriptor
- Species:
- rat
- Route of administration:
- inhalation: aerosol
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 3 363 mg/m³ air (analytical)
- Based on:
- other: read across
- Exp. duration:
- 4 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on read across from PETMP, the 4-h LC50 of PETMA is considered >3.36 mg/L which was the highest attainable concentration of PETMP. Since both substances haver similar visosities, they are assumed to have a similar behaviour when atomised.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 3 360 mg/m³ air
- Quality of whole database:
- read across from valid study, no mortality at highest attainable concentration
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- not required since data on two other routes of exposure are available
Additional information
Justification for classification or non-classification
Based on read across from PETMP, PETMA is assumed to be harmful if swallowed (LD50 = 1500 mg/kg bw, Acute Tox 4, H302) and non-toxic if inhaled (no mortality at highest attainable concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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