Registration Dossier
Registration Dossier
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EC number: 913-400-3 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study period not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Pre-OECD, Pre-GLP study without detailed documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of [(3,7-dimethyloct-6-en-1-yl)oxy]acetaldehyde and [(3,7-dimethyloctyl)oxy]acetaldehyde
- EC Number:
- 913-400-3
- Molecular formula:
- C12H22O2
- IUPAC Name:
- Reaction mass of [(3,7-dimethyloct-6-en-1-yl)oxy]acetaldehyde and [(3,7-dimethyloctyl)oxy]acetaldehyde
- Test material form:
- liquid
- Details on test material:
- Storage condition of test material: PURGE HEADSPACE WITH NITROGEN, REFRIGERATE (35 - 46.5 F / 2 - 8 C)
1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No details
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at least daily
- Necropsy of survivors performed: not mentioned in the report
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2/10 animals died. Death was observed on day 5 and 12.
- Clinical signs:
- Lethargy was observed.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified: criteria not met
- Remarks:
- according to EU CLP Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- The acute oral toxicity test showed an LD50 of >5000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study performed similar to OECD 401 (pre-OECD, pre-GLP) 10 rats were administered the test substance orally at a dose level of 5000 mg/kg bw. During the 14 -day observation period 2/10 rats died. Mortality was observed at day 5 and 12. The clinical sign observed was lethargy. The acute oral LD50 for the test substance in rats was determined to be >5000 mg/kg bw.
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