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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
03 April 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study but the method was only able to determine a high limit value
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
GLP compliance:
yes
Type of method:
static method
Specific details on test material used for the study:
- The infrared (IR) spectrum of the test material measured at this laboratory was confirmed to be identical to that provided by the sponsor.
- In addition, the IR spectrum of the test material after the completion of the experiment was the same as that before the start of the experiment, and it indicated that the test material was stable under the storage conditions.
Key result
Temp.:
25 °C
Vapour pressure:
< 133 Pa
Key result
Temp.:
50 °C
Vapour pressure:
< 133 Pa

The value was regarded as <133 Pa because the vapour pressure was lower than the limit of measurement.

Table 1: Results

Test Temperature (°C)

Vapour Pressure

Measured Value

(mmHg)

Converted Value (Pa)

(1 mmHg = 133 Pa)

25

< 1

< 133

< 1

< 133

< 1

< 133

50

< 1

< 133

< 1

< 133

< 1

< 133
Conclusions:
Under the conditions of this study the vapour pressure of the test material was determined to be < 133 Pa. The vapour pressure was lower than the limit of the measurement.
Executive summary:

The vapour pressure of the test material was investigated in accordance with the standardised guideline OECD 104, under GLP conditions using the static method.

During the study, approximately 0.5 g of test material sample was weighed into a test tube and the test tube was placed in the measurement equipment. The test sample was deaerated under reduced pressure. The test material sample was frozen with liquid nitrogen and then the pressure in the test tube was reduced with the vacuum pump to 10^-2 mmHg order or less. The test material sample was then slowly heated to the test temperature. The vapour pressure of the test material at each test temperature was measured with a mercurial manometer. the measurement was performed in triplicate at 25 and 50°C.

Under the conditions of this study the vapour pressure of the test material was determined to be < 133 Pa. The vapour pressure was lower than the limit of the measurement.

Description of key information

The vapour pressure of the test material was calculated to be 0.000211 Pa (1.59E-06 mm Hg; Modified Grain method) at 25°C using MPBPVP (v1.43).

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

QSAR Determination

The vapour pressure of the test material was calculated using MPBPVP v1.43 (Sept 2010) 2000 U.S. Environmental Protection Agency. Given that the substance is an organic molecule within the Molecular Weight range of the training set compounds, the prediction is considered to be acceptable.

The vapour pressure of the test material was calculated to be 0.000211 Pa (1.59E-06 mm Hg; Modified Grain method) at 25 °C.

Kawashima (2018)

The vapour pressure of the test material was investigated in accordance with the standardised guideline OECD 104, under GLP conditions using the static method. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).

During the study, approximately 0.5 g of test material sample was weighed into a test tube and the test tube was placed in the measurement equipment. The test sample was deaerated under reduced pressure. The test material sample was frozen with liquid nitrogen and then the pressure in the test tube was reduced with the vacuum pump to 10^-2 mmHg order or less. The test material sample was then slowly heated to the test temperature. The vapour pressure of the test material at each test temperature was measured with a mercurial manometer. the measurement was performed in triplicate at 25 and 50°C.

Under the conditions of this study the vapour pressure of the test material was determined to be < 133 Pa. The vapour pressure was lower than the limit of the measurement.