Reaction products of 2,4,6-trichloro-1,3,5-triazine copuled with 3-aminopropyldiethylamine, coupled with 3-acetamidoanilinium chloride, diazotised, coupled with 2,5-Xylidine, coupled with 3-amino-4-hydroxybenzenesulphonamide, further coupled with resorcinol and metallized with iron chloride.

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October from 08th to 12th, 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Reason / purpose for cross-reference:

reference to other study

Remarks:

validated of analytical method

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

adopted July 27, 1995

Deviations:

yes

Remarks:

not impacting the reliability of test results

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

131 g/L

Conc. based on:

test mat.

Incubation duration:

24 - 72 h

Temp.:

20 °C

pH:

ca. 4.4

Details on results:

The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines.
The water solubility of test item was determined to be 131 ± 10 g/l (95 % confidence interval) at 20 ± 1 °C using the shake-flask method for the performance.

Sampling time	Measured concentration (g/l)		Measured pH
	Test vessels	Mean with the 95 % confidence intervals
After 24 h	128	127 ± 3	4.42
	126		4.44
	126		4.44
After 48 h	129	131 ± 16	4.4
	139		4.38
	126		4.42
After 72 h	132	135 ± 14	4.37
	141		4.35
	131		4.39
Solubility of the test item (g/l)		131 ± 10	-
RSD %		3	-
Ultra-pure water		not detected	6.08-6.10

Conclusions:

131 ± 10 g/l at 20 ± 1 °C and pH ca 4.4

Executive summary:

The water solubility of the test item was determined in accordante with the method and procedures outlined into the OECD guideline 105.

A preliminary test for solubility was carried out for the decision whether the column elution method or the flask method has to be used for the performance of the main test. The solubility of the test item was higher than 10 mg/l; therefore, the flask method was used for the main test.

The concentration in the clear aqueous phase was determined by spectrophotometric validate method. The pH of each sample was recorded.

The water solubility of test item was determined to be 131 ± 10 g/l (95 % confidence interval) at 20 ± 1 °C and pH ca 4.4 using the flask method for the performance. The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines.

Conclusion

Water solubility: 131 ± 10 g/l at 20 ± 1 °C and pH ca 4.4

Description of key information

131 ± 10 g/l at 20 ± 1 °C and pH ca 4.4

Key value for chemical safety assessment

Water solubility:

131 g/L

at the temperature of:

20 °C

Additional information

OECD 105 - Flask method