Registration Dossier
Registration Dossier
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EC number: 237-732-7 | CAS number: 13952-84-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- sec-butylamine
- EC Number:
- 237-732-7
- EC Name:
- sec-butylamine
- Cas Number:
- 13952-84-6
- Molecular formula:
- C4H11N
- IUPAC Name:
- butan-2-amine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: 200 mg/kg (10% aqueous solution) and 2000 mg/kg pure
- Duration of exposure:
- 24hours
- Doses:
- 200 and 2000 mg/kg
- No. of animals per sex per dose:
- 6 males/rats
- Control animals:
- no
- Details on study design:
- Doses were applied to the hair-clipped skin of the trunk under an occluding sleeve on each animal. The sleeves were removed 24 hours later and survivors were observed for 7 days.
- Statistics:
- none
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 200 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 2000 mg/kg: contact with the undiluted sample caused pain. Erythema appeared immediately and then became black within 10 minutes. 2 of 3 rats dies overnight (>3 hours). Large areas of skin were completely destroyed in each of the animals.
- Clinical signs:
- other: not recorded.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- LD 50: 200-2000 mg/kg/day
- Executive summary:
Three rats were treated dermally with 2000 mg/kg and three were treated with 200 mg/kg (10% aqueous solution). Doses were applied to the hair clipped skin of the trunk under an occluding sleeve on each animal.The sleeves were removed 24 hours later and survivors were observed for seven days.
2000 mg/kg : contact with the undiluted sample caused pain appeared immediately and then became black within ten minutes.Two of the three rats died overnight (>3hours). Large areas of skin were completely destroyed in each of the animals.
200 mg/kg: contact with 10% dilution also caused pain. Erythema appeared within one minute and persisted without further change. None of the rats died. Scattered scabs were formed on each animal.
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