Registration Dossier
Registration Dossier
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EC number: 271-826-9 | CAS number: 68609-42-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Gadolinium oxide sulfide (Gd2O2S), praseodymium-doped
- EC Number:
- 271-826-9
- EC Name:
- Gadolinium oxide sulfide (Gd2O2S), praseodymium-doped
- Cas Number:
- 68609-42-7
- Molecular formula:
- Gd2O2S
- IUPAC Name:
- digadolinium dioxid sulfide, praseodymium-doped
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality observed
- Clinical signs:
- no clinical signs observed
- Body weight:
- The body weights of all animals increased eventually during the study. A slight decrease in the body
weights in 3 animals within the 1st week was observed. Only in one rat (No 1), stagnation of body
weight was noticed between the first and second week after administration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- GOS is not toxic according to CLP-criteria
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