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EC number: 254-942-4 | CAS number: 40498-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-07-08 - 1981-07-22
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- - Principle of test: comparable to guideline study OECD 420, test was performed in 1981, before OECD guideline was published.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2,3-dihydro-1,4-dihydroxyanthraquinone
- EC Number:
- 254-942-4
- EC Name:
- 2,3-dihydro-1,4-dihydroxyanthraquinone
- Cas Number:
- 40498-13-3
- Molecular formula:
- C14H10O4
- IUPAC Name:
- 2,3-dihydro-9,10-dihydroxyanthracene-1,4-dione
- Details on test material:
- CAS # 40498-13-3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMA
- Source: WISW (SPF Cpb), Winkelmann, Borchen
- Females nulliparous and non-pregnant: yes
- Age at study initiation: 9 weeks (male), 14 weeks (female)
- Weight at study initiation: 169 g (mean; male), 158 g (mean; female)
- Fasting period before study: yes (16 h before and 4 h after application)
- Housing: Makrolon cages (type III), 5 rats per cage
- Diet (e.g. ad libitum): Altromin 1324 pellets
- Water (e.g. ad libitum): tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1.5
- Humidity (%): 60 +/- 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- poloxamer
- Remarks:
- in report named "Lutrol"
- Details on oral exposure:
- application volume: 20 ml/kg bw
- Doses:
- 5,0 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several observations at day of application followed by twice a day (once at weekends/bank holidays)
- Frequency of weighing: at application, after 1 week, after 2 weeks
- Necropsy of survivors performed: yes (spot tests)
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- no
- Clinical signs:
- other: weight loss
- Gross pathology:
- No pathological anatomical findings were reported in any animal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 of the test substance in male and female rats was >5000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study in general comparable to OECD Guideline 420, one dose group, with 5 males and 5 females, fasted, 9 and 14 weeks old Wistar strain rats given a single oral dose of Dihydrochinizarin in Poloxamer (named Lutrol) by gavage at a dose of 5000 mg/kg bw and observed for 14 days.
No animal died during the observation period. Clinical signs reported but not quantified: weight loss
Oral LD50 (rat, males/females) > 5000 mg/kg bw
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