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EC number: 241-644-4 | CAS number: 17671-26-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the analogue justification provided in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- water phase only, separated by pipetting
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- water phase only, separated by pipetting
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- water phase only, separated by pipetting
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: The daphnids did not show any abnormal behaviour throughout the test.
- Effect concentrations exceeding solubility of substance in test medium: yes - Results with reference substance (positive control):
- The EC50 (24 h) of the reference substance potassium dichromate was 0.9 mg/L and hence within the target range of 0.9 - 1.9 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 Jul - 20 Jul 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Appendix of the EU-guideline 92/69/EWG, adopted in 1992
- Deviations:
- yes
- Remarks:
- Spacing factor of test concentrations exceeds 2.2
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Loadings of 1 to 100 mg product/L (nominal) were stirred in test medium for about 24 hours. After a settling time of about 2 hours oil drops were observed on the surface of the water phases with loadings > 3 mg/L. The dissolved phases were transferred with a pipette into the test tubes. Subsequently the neonates were transferred into the separated water phase. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Source: CREASEL, 9800 Deinze, Belgium; delivery: 07 April 2000; batch-no. M280599
- Method of breeding: The neonates used in this test were hatched from ephippia
CULTURE CONDITIONS
- M4 medium according to Elendt
- Hatching of ephippia: approx. 4800 lux, continuous illumination, approx. 20 °C
- Incubation of neonates: 900 lux, 16h light/8 h dark, approx. 20 °C
- Type and amount of food: Scenedesmus subspicatus - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20 °C
- pH:
- 8.1 - 8.2 after 48 h
- Dissolved oxygen:
- 98 - 99% after 48 h
- Nominal and measured concentrations:
- Nominal: 0, 1.0, 3.0, 10, 30, 100 mg/L
Measured (test end): ≤ 0.1 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers
- Type (delete if not applicable): covered with glass plates
- Material, size, fill volume: glass, 100 mL, 50 mL
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Synthetic mineral water (M4 medium according to Elendt) was stirred after addition of the test substance for about 24 h. After a settling time of about 2 h oil drops were observed on the surface of the water phases with loadings > 3 mg/L. The dissolved phases were transferred with a pipette into the test tubes.
OTHER TEST CONDITIONS
- Photoperiod: 16 h light/8 h dark
- Light intensity: 900 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): The number of immobilised daphnids was recorded after 24 and 48 h.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 3 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- water phase only, separated by pipetting
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- water phase only, separated by pipetting
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- water phase only, separated by pipetting
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: The daphnids did not show any abnormal behaviour throughout the test.
- Effect concentrations exceeding solubility of substance in test medium: yes - Results with reference substance (positive control):
- The EC50 (24 h) of the reference substance potassium dichromate was 0.9 mg/L and hence within the target range of 0.9 - 1.9 mg/L.
Referenceopen allclose all
In the range of water solubility no adverse effects of the test substance on Daphnia magna was observed (Table 1). The analytical results presented in Table 2 verify the poor water solubility of the test item.
Table 1: Immobilisation of D. magna exposed to the test substance
Nominal Loading (mg/L) |
Parallel |
Immobilised daphnids after |
|
24 h |
48 h |
||
0 |
1 |
0 |
0 |
2 |
0 |
0 |
|
1 |
1 |
0 |
0 |
2 |
0 |
0 |
|
3 |
1 |
1 |
2 |
2 |
0 |
2 |
|
10 |
1 |
4 (a) |
9 (a) |
2 |
3 (a) |
4 (a) |
|
30 |
1 |
1 |
4 |
2 |
0 |
3 |
|
100 |
1 |
0 |
4 |
2 |
2 |
5 |
(a) The daphnids got stuck at the water surface, probably due to contamination of the test vessels. Therefore, these data were omitted.
Table 2: Analytical monitoring of the nominal loading rates of three test substance concentrations.
Nominal Loading (mg/L) |
Measured concentrations (mg/L) after |
||
0 h |
24 h |
48 h |
|
1 |
0.47 |
<< 0.1 |
<< 0.1 |
10 |
0.46 |
< 0.1 |
<< 0.1 |
100 |
23.6 |
2.7 |
0.1 |
In the range of water solubility no adverse effects of the test substance on Daphnia magna was observed (Table 1). The analytical results presented in Table 2 verify the poor water solubility of the test item.
Table 1: Immobilisation of D. magna exposed to the test substance
Nominal Loading (mg/L) |
Parallel |
Immobilised daphnids after |
|
24 h |
48 h |
||
0 |
1 |
0 |
0 |
2 |
0 |
0 |
|
1 |
1 |
0 |
0 |
2 |
0 |
0 |
|
3 |
1 |
1 |
2 |
2 |
0 |
2 |
|
10 |
1 |
4 (a) |
9 (a) |
2 |
3 (a) |
4 (a) |
|
30 |
1 |
1 |
4 |
2 |
0 |
3 |
|
100 |
1 |
0 |
4 |
2 |
2 |
5 |
(a) The daphnids got stuck at the water surface, probably due to contamination of the test vessels. Therefore, these data were omitted.
Table 2: Analytical monitoring of the nominal loading rates of three test substance concentrations.
Nominal Loading (mg/L) |
Measured concentrations (mg/L) after |
||
0 h |
24 h |
48 h |
|
1 |
0.47 |
<< 0.1 |
<< 0.1 |
10 |
0.46 |
< 0.1 |
<< 0.1 |
100 |
23.6 |
2.7 |
0.1 |
Description of key information
No effects up to the limit of water solubility (D. magna, EU-guideline 92/69/EWG, 1992); read-across
Key value for chemical safety assessment
Additional information
There is no study available, in which the short-term toxicity of the target substance lauryl nonanoate (CAS 17671-26-0) to aquatic invertebrates was assessed. Therefore, a read-across to the structurally related source substance octyl octanoate (CAS 2306-88-9) was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substance is characterized by a similar fatty acid chain length (C8, octanoic acid) as well as alcohol component (C8, octanol) and is therefore considered a suitable representative for the assessment of the acute toxicity of the target substance to aquatic invertebrates. A detailed read-across justification is provided in the analogue justification in IUCLID Section 13.
The available study with the source substance octyl octanoate (CAS 2306-88-9) was conducted according to EU guideline 92/69/EWG and GLP. In a static test, D. magna was exposed to five, nominal loading levels ranging from 1.0 to 100 mg/L with a spacing factor of 3, for 48 h. The test solution was prepared as water accommodated fraction and the test item concentrations were analytically verified at the beginning and end of the test by GC. After 48 h, no adverse effects of the test substance in the range of the water solubility were observed on D. magna. The analytical results confirmed the poor water solubility of the test item.
Based on the structural and chemical similarity of the target and source substance, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that lauryl nonanoate (CAS 17671-26-0) will not exhibit short-term effects to aquatic invertebrates up to the limit of water solubility.
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