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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Referenceopen allclose all

Reference Type:
other: ECOSAR calculation
Title:
Unnamed
Year:
2017
Report date:
2017
Reference Type:
other: Estimation software
Title:
Estimation Programs Interface Suite for Microsoft Windows, v4.10
Author:
US-EPA
Year:
2012
Bibliographic source:
United States Environmental Protection Agency, Washington, DC, USA

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
ECOSAR v1.11: Estimation of acute toxicity to fish for chemical class "Schiff Bases" and "Neutral Organic SAR (Baseline Toxicity)"
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
EC Number:
212-975-1
EC Name:
1-[[(2-hydroxyphenyl)imino]methyl]-2-naphthol
Cas Number:
894-93-9
Molecular formula:
C17H13NO2
IUPAC Name:
1-[(1E)-[(2-hydroxyphenyl)imino]methyl]naphthalen-2-ol

Test organisms

Test organisms (species):
other: fish

Study design

Water media type:
freshwater
Total exposure duration:
96 h

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.637 mg/L
Nominal / measured:
estimated
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Remarks on result:
other: ECOSAR class: "Schiff Bases-Azomethine"; Substance within applicability domain of the model.
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
11.546 mg/L
Nominal / measured:
estimated
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Remarks on result:
other: "Neutral Organic SAR (Baseline Toxicity)"; Substance is a neutral organic chemical, baseline toxicity value provided to be able to quantify the amount of excess toxicity to fish.

Applicant's summary and conclusion

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