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EC number: 271-402-3 | CAS number: 68554-12-1
No mortality or signs of toxicity were noted during the study. Fur loss on the neck and hardened residual test substance on the ears and head were noted in animals treated with the test substance at dose concentrations of 10 and 25%.
Body weight changes in test substance-treated animals were comparable to the controls.
A study was conducted to assess the potential of Resin acids and Rosin acids, hydrogenated, potassium salts to produce delayed type hypersensitivity in the mouse. Using the Local Lymph Node Assay, five (CBA/CaCruBR) female mice per group were exposed to 50 µL (25 µL per ear) EKC 2004-0223 (Resin acids and Rosin acids, hydrogenated, potassium salts) at test concentrations of 5, 10, and 25% in a 4:1 ethanol:distilled water vehicle. Three days after the last test substance administration, the animals were injected via the tail vein with 250 µL of phosphate buffered saline containing ^3H-methyl thymidine and euthanized 5 hours later. Single cell suspensions of lymph node cells were made, incubated overnight, and the incorporation of ^3HTdR was measured by β-scintillation counting. A stimulation index of greater than 3 was recorded in the 25% dose concentration group. Since at least one concentration resulted in a Stimulation Index ≥ 3, EKC 2004-0223 (Resin acids and Rosin acids, hydrogenated, potassium salts) is a considered to be a dermal sensitizer according to the interpretative criteria of the protocol. However the reliability of the finding is unclear given the negative LLNA result obtained on a sample of Resin acids and rosin acids, potassium salts together with the large amount of supporting negative sensitisation data available on other members of this category.
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