Registration Dossier
Registration Dossier
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EC number: 222-940-2 | CAS number: 3674-09-7
Endpoint summary
Administrative data
Description of key information
Skin corrosion/irritation
Experimental data on the potential of skin corrosion/irritation are available for the substance.
The substance is resulted skin irritant during an acute toxicity study (skin irritation); vesicle formation are reported.
The following deepening for this property has been performed.
As a result of an overall assessment of the QSAR predictions (detailed in Table below) the substance can be classified for skin irritation.
|
Name of the software |
Model/module |
Model type |
Result |
Skin irritation |
QSAR Toolbox |
Skin irritation/corrosion Inclusion rules by BfR |
Structural alerts |
Aliphatic alpha-halogen-esters
Structural alerts associated with chemicals that can cause irritation.
Skin irritation potential, can be related to a combination of MW and log Pow, e.g., chemicals with MW < 200 and log Pow of > 2 had enhanced skin irritation potential.
For chemicals with MW < 200 skin corrosion potential is enhanced and appears to be independent of log Pow.
[Hulzebos E. et al. 2005]
MW: 156.99 log Pow: 1.3 [Predicted]
|
Danish (Q)SAR database |
Severe Skin Irritation in Rabbit |
Qualitative
|
Model results:
Battery POS_IN
CASE Ultra POS_OUT
Leadscope POS_IN
SciQSAR POS_IN
This results are considered reliable.
|
|
Toxtree |
Skin irritation/ skin corrosion |
Structural alerts |
Irritating to skin |
|
Abbreviations INC: inconclusive. A definite call within the defined applicability domain could not be made. NEG: negative POS: positive IN: inside applicability domain OUT: outside applicability domain |
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Serious eye damage/eye irritation
Experimental data on this property are available.
The substance is resulted eye irritant during an acute toxicity study (eye irritation); vesicle formation are reported.
Classification provided by companies to ECHA in CLP notifications this substance causes eye damage.
Specific target organ toxicity - single
Vapours of the substance cause an irritation on the mucous membranes of the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Skin corrosion/irritation
Available data are deemed sufficient for classify the substance as Skin Irrit. 2; H315.
Serious eye damage/eye irritation
Available data are deemed sufficient for classify the substance as Eye Irrit. 2; H319.
Specific target organ toxicity - single
Overall, this data is deemed sufficient for classify the substance as STOT SE 3; H335.
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