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EC number: 231-640-0 | CAS number: 7665-72-7
Chamber atmosphere analysis:
The mean daily time-weighted average (THA) analytical concentration was within ±2% of the intended target concentration for each exposure group. Moreover, there was close agreement between the mean daily TWA analytical concentration and mean daily nominal concentration for each exposure group, indicating that test material losses were minimal in the vapor generator and exposure systems.
In a subchronic inhalation toxicity study similar to OECD 413, tert-Butyl glycidyl ether was administered to 10 Fischer 344 rats/sex/concentration by whole body exposure at concentrations of 0, 25, 75 and 225 ppm (0, 0.13, 0.40 and 1.19 mg/L) for 6 hours per day/5 days per week during a 13 week-period. Exposure of male and female rats to 225 ppm results in decreased body weight gain and concomitant changes in organ weights. Haematology parameters and bone marrow histopathology indicated that they were not adversely affected. Clinical chemistries and urinalyses revealed no changes diagnostic of adverse treatment-related effects in any target organs. Histopathologic examinations revealed no primary treatment-related effects in any organ or tissue except the nasal mucosa. The changes in rats exposed to 225 ppm involved primarily the respiratory epithelial-lined regions of the nasal mucosa in the anterior portion of the nostril; the more posterior regions of the turbinate mucosa lined by olfactory epithelium were affected to a lesser degree. Minimal treatment-related effects were observed only in the respiratory epithelium in most of the animals exposed to 75 ppm. There were no treatment-related changes in any organ or tissue of rats exposed to 25 ppm.
The NOAEC (local) is 25 ppm and NOAEC (systemic) is 75 ppm.
This study was also conducted with mice (10/group) and rabbits (4/group). Similar effects observed in the rat have been also seen in mice as well as in rabbits.
This subchronic inhalation toxicity study in the rat is acceptable and satisfies the requirement for a subchronic inhalation study in the rat.
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